Predictors of Carotid Thickness and Plaque Progression During a Decade: The Multi-Ethnic Study of Atherosclerosis

Details

• Personal Author:
  Astor BC ; Gassett A ; Gepner AD ; Kaufman JD ; Korcarz CE ; Kronmal RA ; Liu KJ ; Sheppard L ; Stein JH ; Tattersall MC
• Description:
  Background and Purpose: Carotid artery intima-media thickness (IMT) and plaque are noninvasive markers of subclinical arterial injury that predict incident cardiovascular disease. We evaluated predictors of longitudinal changes in IMT and new plaque during a decade in a longitudinal multiethnic cohort. Methods: Carotid IMT and plaque were evaluated in Multi-Ethnic Study of Atherosclerosis (MESA) participants at exams 1 and 5, a mean (standard deviation) of 9.4 (0.5) years later. Far wall carotid IMT was measured in both common and internal carotid arteries. A plaque score was calculated from all carotid segments. Mixed-effects longitudinal and multivariate regression models evaluated associations of baseline risk factors and time-updated medication use with IMT progression and plaque formation. Results: The 3441 MESA participants were aged 60.3 (9.4) years (53% women; 26% blacks, 22% Hispanic, 13% Chinese); 1620 (47%) had carotid plaque. Mean common carotid artery IMT progression was 11.8 (12.8) um/year, and 1923 (56%) subjects developed new plaque. IMT progressed more slowly in Chinese (B=-2.89; P=0.001) and Hispanic participants (B=-1.81; P=0.02), and with higher baseline high-density lipoprotein cholesterol (per 5 mg/dL; B=-0.22; P=0.03), antihypertensive use (B=-2.06; P=0.0004), and time on antihypertensive medications (years; B=-0.29; P<0.0001). Traditional risk factors were associated with new plaque formation, with strong associations for cigarette use (odds ratio, 2.31; P<0.0001) and protection by black ethnicity (odds ratio, 0.68; P<0.0001). Conclusions: In a large, multiethnic cohort with a decade of follow-up, ethnicity was a strong, independent predictor of carotid IMT and plaque progression. Antihypertensive medication use was associated with less subclinical disease progression. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Cohort Studies Epidemiology Occupational Health Race Factors Safety Sex Characteristics
• Keywords:
  Author Keywords: Atherosclerosis Cardiovascular Disease Carotid Arteries Cohort Studies Exposure Assessment Gender Factors Heart Disease Longitudinal Study Racial Factors Risk Factors
• ISSN:
  0039-2499
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; OSHA Region 10 ; OSHA Region 5 ; Washington ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  45
• Issue:
  11
• NIOSHTIC Number:
  nn:20054802
• Citation:
  Stroke 2014 Nov; 45(11):3257-3262
• Contact Point Address:
  James H. Stein, MD, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Room H4/520 CSC (MC 3248), Madison, WI 53792
• Email:
  jhs@medicine.wisc.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Stroke
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a69209b5a85d77936dc6345c472fe613299efce36360f1ddfe1e56faec6c8af61c9f8948d96e11110715104847ad26f1aa5d33a9a78c0368dd4efd55f5bb8d3b
• Download URL:
  https://stacks.cdc.gov/view/cdc/217232/cdc_217232_DS1.pdf
• File Type:
  [PDF - 514.09 KB ]