Maternal Titanium Dioxide Nanomaterial Inhalation Exposure Compromises Placental Hemodynamics

Details

• Personal Author:
  Abukabda AB ; Batchelor TP ; Bowdridge EC ; Friend S ; Garner KL ; Goldsmith WT ; McBride CR ; Nurkiewicz TR
• Description:
  The fetal consequences of gestational engineered nanomaterial (ENM) exposure are unclear. The placenta is a barrier protecting the fetus and allowing transfer of substances from the maternal circulation. The purpose of this study was to determine the effects of maternal pulmonary titanium dioxide nanoparticle (nano-TiO2) exposure on the placenta and umbilical vascular reactivity. We hypothesized that pulmonary nano-TiO2 inhalation exposure increases placental vascular resistance and impairs umbilical vascular responsiveness. Pregnant Sprague-Dawley rats were exposed via whole-body inhalation to nano-TiO2 with an aerodynamic diameter of 188 +/- 0.36 nm. On gestational day (GD) 11, rats began inhalation exposures (6 h/exposure). Daily lung deposition was 87.5 +/- 2.7 microg. Animals were exposed for 6 days for a cumulative lung burden of 525 +/- 16 microg. On GD 20, placentas, umbilical artery and vein were isolated, cannulated, and treated with acetylcholine (ACh), angiotensin II (ANGII), S-nitroso-N-acetyl-DL-penicillamine (SNAP), or calcium-free superfusate (Ca2+-free). Mean outflow pressure was measured in placental units. ACh increased outflow pressure to 53 +/- 5 mmHg in sham-controls but only to 35 +/- 4 mmHg in exposed subjects. ANGII decreased outflow pressure in placentas from exposed animals (17 +/- 7 mmHg) compared to sham-controls (31 +/- 6 mmHg). Ca2+-free superfusate yielded maximal outflow pressures in sham-control (63 +/- 5 mmHg) and exposed (30 +/- 10 mmHg) rats. Umbilical artery endothelium-dependent dilation was decreased in nano-TiO2 exposed fetuses (30 +/- 9%) compared to sham-controls (58 +/- 6%), but ANGII sensitivity was increased (-79 +/- 20% vs -36 +/- 10%). These results indicate that maternal gestational pulmonary nano-TiO2 exposure increases placental vascular resistance and impairs umbilical vascular reactivity. [Description provided by NIOSH]
• Subjects:
  Blood Fetus Laboratories Lung Occupational Health Pregnancy Respiratory System Safety Titanium
• Keywords:
  Author Keywords: Engineered Nanomaterials Circulatory System Exposure Assessment Hemodynamics Inhalation Laboratory Animals Laboratory Testing Microcirculation Nanomaterials Nanoparticles Nanotechnology Placenta Pulmonary System Titanium Dioxide Titanium Dioxide Nanoparticles

  More +
• ISSN:
  0041-008X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  51-61
• Volume:
  367
• NIOSHTIC Number:
  nn:20054789
• Citation:
  Toxicol Appl Pharmacol 2019 Mar; 367:51-61
• Contact Point Address:
  Timothy R. Nurkiewicz, Department of Physiology and Pharmacology, 64 Medical Center Drive, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26505-9229, USA
• Email:
  tnurkiewicz@hsc.wvu.edu
• CAS Registry Number:
  Titania (CAS RN 13463-67-7)
• Federal Fiscal Year:
  2019
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology and Applied Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7fcfaeb901383dc1dd86b73cc7b86d936b5b092ed2c51cd6150b4f3761d8a168b2675d463e20f8a112575b5bf3dd4580cbcc43ff36ccd90802341b468d74b83d
• Download URL:
  https://stacks.cdc.gov/view/cdc/217221/cdc_217221_DS1.pdf
• File Type:
  [PDF - 2.24 MB ]