Use of a Methacholine Challenge Test to Diagnose Work-Related Asthma

Details

• Corporate Authors:
  Michigan State University. College of Human Medicine
• Description:
  In the absence of the availability of a definitive antigen challenge test, the diagnosis of work-related asthma has remained challenging. A 2015 study from Quebec, where specific antigen challenge testing is routinely performed in the evaluation of patients with possible sensitization to a workplace exposure, provides new data on the value of methacholine challenge testing in diagnosing work-related asthma caused by sensitization to a substance at work. Practitioners from the Hôpital du Sacré-Coeur in Montreal reviewed all 1,012 patients they evaluated from 1983 to 2011 who had completed a specific antigen challenge test and a methacholine challenge test for work-up of suspected work-related asthma. Individuals who had a positive specific antigen challenge test were considered to have work-related asthma. They divided the population into those who were still working when they were tested and those who were off work. A summary of the specific antigen and methacholine challenge tests that were performed while the patient was still working is shown in Table I and a summary of the findings for those no longer at work is shown in Table II. [Description provided by NIOSH]
• Subjects:
  Asthma, Occupational Diagnosis Methacholine Compounds Occupational Exposure Occupational Health Safety
• Keywords:
  Clinical Diagnosis Diagnostic Techniques Methacholines Occupational Asthma Occupational Exposure
• Publisher:
  Michigan State University-College of Human Medicine
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Newsletter
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-4
• Volume:
  27
• Issue:
  1
• NIOSHTIC Number:
  nn:20054644
• Citation:
  Project S.E.N.S.O.R. News 2015 Oct; 27(1):1-4
• Contact Point Address:
  MSU-CHM, 117 West Fee Hall, East Lansing, MI 48824-1316
• CAS Registry Number:
  Methacholine (CAS RN 55-92-5)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Michigan State University
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Project S.E.N.S.O.R. News
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:02f0f2e2426a150ade1f8dfa78d9d974f9e561c3157075c648528665238ca71ce85d42986a782e3f5528800848590e53eb6a0a88b6349b626a0f2c551b263183
• Download URL:
  https://stacks.cdc.gov/view/cdc/217118/cdc_217118_DS1.pdf
• File Type:
  [PDF - 196.88 KB ]