Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study

Details

• Personal Author:
  Andrew, Michael E. ; Burch JB ; Charles LE ; Fekedulegn D ; Hartley TA ; Holst MM ; Mnatsakanova A ; Tinney-Zara C ; Violanti JM ; Wirth MD
• Description:
  Objective: To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort. Methods: A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification. Results: Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30 kg/m2 versus the day shift. Conclusions: Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork. [Description provided by NIOSH]
• Subjects:
  Biomarkers Law Enforcement Neoplasms Occupational Health Safety Shift Work Schedule
• Keywords:
  Author Keywords: Cardiovascular Disease BMI Body Mass Index Cardiovascular System Disease Inflammation Law Enforcement Officer LEO Leukocytes Police Officers Police Work Proteins Shift Work Shiftwork Shift Workers Tumors

  More +
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Contract ; Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; South Carolina ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  391-396
• Volume:
  61
• Issue:
  5
• NIOSHTIC Number:
  nn:20054474
• Citation:
  J Occup Environ Med 2019 May; 61(5):391-396
• Contact Point Address:
  Michael D. Wirth, MSPH, PhD, Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Room 233, Columbia, SC 29208
• Email:
  wirthm@mailbox.sc.edu
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Public Safety
• Performing Organization:
  State University of New York at Buffalo
• Peer Reviewed:
  True
• Start Date:
  20100901
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eedd639c14c045450e2358dcf913896700cf492972eb4d2f8e112a955d3d8f668afd23fd0eeb3d19c2fd19a46b4535bfacbf4b0bcee388b6484ea1511241be2f
• Download URL:
  https://stacks.cdc.gov/view/cdc/217031/cdc_217031_DS1.pdf
• File Type:
  [PDF - 655.24 KB ]