The Neurobiology of Borderline Personality Disorder

Details

• Personal Author:
  Bassir Nia A ; Bulbena-Cabré A ; Goodman M ; New AS ; Perez-Rodriguez MM ; Zipursky G
• Description:
  Evidence clearly suggests that borderline personality disorder (BPD) is substantially heritable and at least as heritable as other major psychiatric disorders. Brain imaging studies have suggested a dysregulation in top-down control of emotions and behavior in BPD; however, this model is also seen in other disorders, such as panic disorder. Abnormalities in the oxytocin and opioid systems may underlie the interpersonal dysfunction characteristic of BPD. An impairment in emotional interoception (a disconnect between heightened objectively measured emotional responses and blunted subjective appreciation of those responses) may be a core feature of BPD. [Description provided by NIOSH]
• Subjects:
  Behavior Genetics Nervous System Occupational Health Safety
• Keywords:
  Alexithymia Author Keywords: Borderline Personality Disorder Brain Function Emotion Dysregulation Genetic Factors Impulsive Aggression Neuroimaging Neurological System Neurophysiology Opioids Oxytocin Psychological Disorders

  More +
• ISSN:
  0193-953X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  41
• Issue:
  4
• NIOSHTIC Number:
  nn:20054398
• Citation:
  Psychiatr Clin North Am 2018 Dec; 41(4):633-650
• Contact Point Address:
  Maria Mercedes Perez-Rodriguez MD, PhD, Department of Psychiatry, One Gustave L Levy Place, Box # 1230, New York, NY 10029
• Email:
  mercedes.perez@mssm.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Psychiatric Clinics of North America
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3cd2f953b846add152fbc0104f027a5b1d90aad7cb7ac136d0c2a321d23c3affd96c6f7a60a071877f91e7c3e1dfd7868701e83753db5b3d69a93fcfe2d23354
• Download URL:
  https://stacks.cdc.gov/view/cdc/216974/cdc_216974_DS1.pdf
• File Type:
  [PDF - 212.94 KB ]