Workplace Strategies to Prevent Sitting-Induced Endothelial Dysfunction

Details

• Personal Author:
  Benzo RM ; Carr LJ ; Casey DP ; Hughes WE ; Kruse NT
• Description:
  Prolonged sitting induces endothelial dysfunction in healthy young adults, which has been demonstrated to be offset by intermittent fidgeting and standing. No information exists on the effect of sitting and endothelial dysfunction in sedentary middle-age adults, and whether common workplace counterinterventions (i.e., desk standing/desk pedaling) mitigate sitting-induced endothelial dysfunction. Purpose: The objective of this study was to examine whether breaking up prolonged sitting with intermittent standing or underdesk pedaling prevents sitting-induced popliteal artery endothelial dysfunction in middle-age sedentary, overweight/obese office workers. Hypothesis: We tested the hypothesis that sitting-induced leg endothelial dysfunction would be prevented by intermittent standing or desk pedaling. Methods: Thirteen middle-age, sedentary overweight/obese subjects (10 men, 3 women; age, 38 +/- 3 yr; body mass index, 29.7 +/- 2 kg·m-2) participated in three separate testing sessions in a randomized order: 1) 4 h of uninterrupted sitting, 2) 4 h of sitting interrupted with four 10-min bouts of standing, and 3) 4 h of sitting interrupted with four 10-min bouts of light-intensity desk pedaling. Doppler ultrasound-measured popliteal artery flow-mediated dilation and associated measures (e.g., shear rate, blood velocity) were measured immediately before and immediately after each intervention (sit, stand, and desk pedaling). Results: Four hours of uninterrupted sitting induced a significant impairment in popliteal artery flow-mediated dilation (baseline: 3.1% +/- 0.3%, post: 1.6% +/- 0.5%; P < 0.05). Interestingly, neither intermittent standing (baseline: 3.2% +/- 0.4%, post: 1.9% +/- 0.5%; P < 0.05) nor intermittent desk pedaling (baseline: 3.2% +/- 0.4%, post: 1.9% +/- 0.4%; P < 0.05) was effective at preventing excessive sitting-induced endothelial dysfunction. Conclusions: Prolonged sitting-induced leg endothelial dysfunction cannot be prevented by brief intermittent bouts of standing or desk pedaling in middle-age sedentary overweight/obese adults. [Description provided by NIOSH]
• Subjects:
  Age Factors Ergonomics Occupational Health Safety Sex Characteristics
• Keywords:
  Age Factors Author Keywords: Flow-mediated Dilation BMI Body Mass Index Endothelial Cells Gender Factors Intervention Effectiveness Obesity Office Workers Pedaling Physical Exercise Physiological Effects Sedentary Sedentary Lifestyle Sitting Standing

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• ISSN:
  0195-9131
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  50
• Issue:
  4
• NIOSHTIC Number:
  nn:20054299
• Citation:
  Med Sci Sports Exerc 2018 Apr; 50(4):801-808
• Contact Point Address:
  Darren P. Casey, Ph.D., Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA 52242
• Email:
  darren-casey@uiowa.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Medicine and Science in Sports and Exercise
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a363b964c0a91f5121c3a4f3b6304952f269e1afe8ee44e04b8d038621e3fdbafb6a8caa349177fb7e9f688e8a260a0ec7e42d82daa022678ca041ad62549f47
• Download URL:
  https://stacks.cdc.gov/view/cdc/216891/cdc_216891_DS1.pdf
• File Type:
  [PDF - 236.53 KB ]