Acute Vibration Induces Peripheral Nerve Sensitization in a Rat Tail Model: Possible Role of Oxidative Stress and Inflammation

Details

• Personal Author:
  Krajnak, Kristine M. ; Pacurari M ; Waugh, Stacey
• Description:
  Prolonged occupational exposure to hand-held vibrating tools leads to pain and reductions in tactile sensitivity, grip strength and manual dexterity. The goal of the current study was to use a rat-tail vibration model to determine how vibration frequency influences factors related to nerve injury and dysfunction. Rats were exposed to restraint, or restraint plus tail vibration at 62.5 Hz or 250 Hz. Nerve function was assessed using the current perception threshold (CPT) test. Exposure to vibration at 62.5 and 250 Hz, resulted in a reduction in the CPT at 2000 and 250-Hz electrical stimulation (i.e. increased ABeta and Adelta nerve fiber sensitivity). Vibration exposure at 250 Hz also resulted in an increased sensitivity of C-fibers to electrical stimulation and thermal nociception. These changes in nerve fiber sensitivity were associated with increased expression of interleukin (IL)-1Beta and tumor necrosis factor (TNF)-alpha in ventral tail nerves, and increases in circulating concentrations of IL-1Beta in rats exposed to 250-Hz vibration. There was an increase in glutathione, but no changes in other measures of oxidative activity in the peripheral nerve. However, measures of oxidative stress were increased in the dorsal root ganglia (DRG). These changes in pro-inflammatory factors and markers of oxidative stress in the peripheral nerve and DRG were associated with inflammation, and reductions in myelin basic protein and post-synaptic density protein (PSD)-95 gene expression, suggesting that vibration-induced changes in sensory function may be the result of changes at the exposed nerve, the DRG and/or the spinal cord. [Description provided by NIOSH]
• Subjects:
  Laboratories Nervous System Occupational Health Safety Vibration
• Keywords:
  Author Keywords: Cytokines Cytokines Hand-arm Vibration Syndrome HAVS Laboratory Animals Oxidative Stress Reactive Oxygen Species ROS Sensory Tests Sensory Thresholds Spinal Cord Vibration Exposure

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• ISSN:
  0306-4522
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Mississippi ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  263-272
• Volume:
  398
• NIOSHTIC Number:
  nn:20054175
• Citation:
  Neuroscience 2019 Feb; 398:263-272
• Contact Point Address:
  Kristine Krajnak, NIOSH/HELD/ECTB, 1095 Willowdale Road, MS 2027, Morgantown, WV 26505, United States
• Email:
  ksk1@cdc.gov
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing ; Wholesale and Retail Trade
• Peer Reviewed:
  True
• Source Full Name:
  Neuroscience
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e46db3145af837aab0ebdba58eb54a3f9ca2fce22c341aa449b502e7a93f071dea159919a3713c26d2c869f58f54bf703182b16a582cb7eea7f6a427eb74298c
• Download URL:
  https://stacks.cdc.gov/view/cdc/216791/cdc_216791_DS1.pdf
• File Type:
  [PDF - 1.28 MB ]