The Molecular Epidemiology of DNA Repair Polymorphisms in Carcinogenesis

Details

• Personal Author:
  Brandt-Rauf PW ; Li Y ; Long C ; Monaco R
• Description:
  VC provides an instructive model for the study of the role of DNA repair polymorphisms in chemical carcinogenesis. A detailed understanding of the molecular biology of VC carcinogenesis has provided new ways of studying the molecular epidemiology of VC carcinogenesis in exposed humans, which in turn may provide the basis for new approaches to the prevention and treatment of VC-related cancer. This model could also have much broader implications, since other potential carcinogenic exposures share some of the same molecular biologic pathways of damage and repair as VC similar molecular epidemiologic biomarkers could be useful for monitoring their carcinogenic process and the effect of altered susceptibility due to changes in DNA repair capability. Such studies in additional model systems would further help to define the exact significance of DNA repair polymorphisms in the development of human cancers. [Description provided by NIOSH]
• Subjects:
  Biomarkers Carcinogens Epidemiology Hazardous Substances Mutagens Neoplasms Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Cancer Carcinogenesis DNA Damage Hazardous Materials Mutagenesis Risk Factors Vinyl Chloride
• Publisher:
  InTech
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20054168
• Citation:
  New research directions in DNA repair. Chen C ed. Rijeka, Croatia: InTech, 2013 May; :579-595
• Email:
  pwb1@uic.edu
• CAS Registry Number:
  Vinyl chloride (CAS RN 75-01-4)
• Editor(s):
  Chen C
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  False
• Start Date:
  20010701
• Source Full Name:
  New research directions in DNA repair
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f2f0152690d25ba18ffe1fcea03d89cfffd054a45236d0faaa766d375c242ffb6a2042a4dd3d3e9474498f8133fd6e600b95a2e761e3634ab4893afa3cc6761f
• Download URL:
  https://stacks.cdc.gov/view/cdc/216786/cdc_216786_DS1.pdf
• File Type:
  [PDF - 770.69 KB ]