Residual Isocyanates in Medical Devices and Products: A Qualitative and Quantitative Assessment

Details

• Personal Author:
  Ahsan S ; Bello D ; Biswas S ; Franklin G ; Harari H ; Liu Y ; Nedrelow J ; Raynaud S ; Sterling DA
• Description:
  We conducted a pilot qualitative and quantitative assessment of residual isocyanates and their potential initial exposures in neonates, as little is known about their contact effect. After a neonatal intensive care unit (NICU) stockroom inventory, polyurethane (PU) and PU foam (PUF) devices and products were qualitatively evaluated for residual isocyanates using Surface SWYPE(TM). Those containing isocyanates were quantitatively tested for methylene diphenyl diisocyanate (MDI) species, using UPLC-UV-MS/MS method. Ten of 37 products and devices tested, indicated both free and bound residual surface isocyanates; PU/PUF pieces contained aromatic isocyanates; one product contained aliphatic isocyanates. Overall, quantified mean MDI concentrations were low (4,4'-MDI = 0.52 to 140.1 pg/mg) and (2,4'-MDI = 0.01 to 4.48 pg/mg). The 4,4'-MDI species had the highest measured concentration (280 pg/mg). Commonly used medical devices/products contain low, but measurable concentrations of residual isocyanates. Quantifying other isocyanate species and neonatal skin exposure to isocyanates from these devices and products requires further investigation. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Health Care Facilities Workforce And Services Infant, Newborn Isocyanates Occupational Health Safety
• Keywords:
  4,4'methylenebisphenyl Isocyanate Environmental Exposure Health Care Facilities MDI Medical Equipment Neonates Polyurethane Foams
• ISSN:
  1178-6302
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 6 ; Texas ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  175-190
• Volume:
  10
• NIOSHTIC Number:
  nn:20053770
• Citation:
  Environ Health Insights 2016 Oct; 10:175-190
• Contact Point Address:
  Youcheng Liu, Department of Environmental and Occupational Health Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA
• Email:
  youcheng-liu@unthsc.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Environmental Health Insights
• End Date:
  20130831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d1b91d561f40966359ca300a37363c9ebf55251fee7156d13b89365a73d5af0e6bec2fa90599d7945aaa8dc437946e8d5baa329e5b8fba6a1ac8e1aab7097c7a
• Download URL:
  https://stacks.cdc.gov/view/cdc/216477/cdc_216477_DS1.pdf
• File Type:
  [PDF - 1.30 MB ]