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Handbook for developing evidence-based recommendations. Version 1.2
  • Published Date:
    November 1, 2013
  • Language:
Filetype[PDF-717.96 KB]

  • Personal Authors:
  • Description:
    01. Introduction -- 02. Formulating Questions -- 03. Choosing and Ranking Outcomes -- 04. Evidence Retrieval -- 05. Type or Quality of Evidence -- 06. GRADE Criteria Determining Type or Quality of Evidence -- 07. Criteria for Downgrading Evidence Level -- 08. Criteria for Upgrading Evidence Level -- 09. Indirect Evidence -- 10. Overall Evidence Type -- 11. Pooling Effect Estimates -- 12. Evidence Tables -- 13. Health Economic Analyses -- 14. Values and Preferences -- 15. Balance of Desirable and Undesirable Effects -- 16. Baseline Risk Estimates -- 17. Formulating Recommendations -- 18. Presenting Recommendations -- 19. Further Research Needs and Priorities -- 20. References -- Appendix 1. Example of Applying GRADE Framework -- Appendix 2. Data Extraction Forms -- Appendix 3. Using GRADEpro Software for Preparing Evidence Tables -- Appendix 4. Using Review Manager (RevMan) Software.

    The U.S. Advisory Committee on Immunization Practices (ACIP) provides expert external advice and guidance to the Director of the Centers for Disease Control and Prevention (CDC) and the Secretary of the Department of Health and Human Services (HHS) on use of vaccines and related agents for control of vaccine-preventable disease in the U.S. civilian population.

    The ACIP unanimously voted during its October 2010 meeting to adopt the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach for developing evidence-based recommendations. The purpose of this handbook is to provide guidance to the ACIP workgroups on using the GRADE approach for assessing the type or quality of evidence and for using that evidence to inform recommendations. Key factors for developing recommendations include the balance of benefits and harms, type or quality of evidence, values and preferences, and health economic analyses.

    This handbook for developing evidence-based recommendations for immunization builds on the GRADE handbook and work of the ACIP’s Evidence Based Recommendations Work Group. The findings and conclusions in this handbook are those of the authors and do not necessarily represent the views of the CDC.

    Suggested citation: Ahmed F. U.S. Advisory Committee on Immunization Practices Handbook for Developing Evidence-based Recommendations. Version 1.2. Atlanta, GA: Centers for Disease Control and Prevention (CDC); 2013.

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