At Diagnosis of Hepatocellular Carcinoma, African Americans with Hepatitis C Have Better Liver Function than Other Patients

Details

• Personal Author:
  Berera D ; Branch AD ; Perumalswami PV ; Schiano TD ; Schwartz ME ; Sung JC ; Winters AC ; Wyatt B
• Description:
  Liver cancer is the fifth most common site of cancer in men worldwide and the second leading cause of site-specific cancer-related death. Hepatocellular carcinoma (HCC) is by far the most common histological cell type, accounting for 90% of all liver cancers in the United States. As of 2008, the worldwide incidence and mortality of liver cancer were essentially equal, highlighting the urgent need for better strategies for prevention and treatment. The prognosis for most patients with HCC is grim: 5-year survival rate ranges between 6% and 28% North America and Western Europe. Early detection allows the use of lifesaving interventions that have the potential to be curative. When these interventions are applied to early-stage HCC, 5-year survival rates are reported to exceed 50%, underscoring the importance of early detection and equal access to potentially curative treatments. Published data show that there are race-related and ethnicity-related differences in HCC incidence, surveillance, diagnosis, and treatment in the United States. African American patients have an elevated incidence of HCC and high HCC-related mortality. According to the National Institutes of Health Surveillance, Epidemiology, and End Results database, during the 2005 to 2007 time interval, the HCC incidence rate in African American individuals was 7.6 per 100,000, which is more than 1.5-fold higher than the national average. In addition, African Americans have lower rates of HCC screening than patients of other races. African American patients present with more advanced HCC and are offered curative surgical therapy less often than members of other races. African American patients have significantly higher in-hospital HCC-related mortality than whites, as well as decreased overall survival. In the United States, chronic infection with the hepatitis C virus (HCV) is a leading risk factor for HCC and has elevated prevalence in African American individuals. This study sought to identify clinical characteristics of patients with a history of HCV infection and HCC that might place non-Hispanic black patients at a survival disadvantage. [Description provided by NIOSH]
• Subjects:
  Diagnosis Liver Mortality Neoplasms Occupational Health Race Factors Safety Viral Diseases
• Keywords:
  Cancer Rates Carcinomas Chronic Inflammation Cirrhosis Clinical Diagnosis Clinical Symptoms Health Care Hepatitis C Hepatotoxicity Hepatotoxins Intervention Liver Cancer Liver Disease Liver Function Liver Tumors Medical Screening Medical Treatment Mortality Rates Racial Factors Surveillance Survival Rate Viral Infections

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• ISSN:
  2046-2484
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  109-112
• Volume:
  12
• Issue:
  4
• NIOSHTIC Number:
  nn:20053722
• Citation:
  Clin Liver Dis 2018 Oct; 12(4):109-112
• Contact Point Address:
  Adam C. Winters, M.D., Department of Internal Medicine, Icahn School of Medicine at Mount Sinai Medical Center, 1 Gustave L. Levy Pl., New York, NY 90029
• Email:
  adam.c.winters@gmail.com
• Federal Fiscal Year:
  2019
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Clinical Liver Disease
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:42f7d2b06ccbefbecc31a98dd98ae7e36962902730e4aee0512f19055fbae5bf0e02cd8938d826c4280f5c02390fb4710cf534deadf91581b818cac07dab0346
• Download URL:
  https://stacks.cdc.gov/view/cdc/216434/cdc_216434_DS1.pdf
• File Type:
  [PDF - 108.67 KB ]