Solvents and the Skin

Details

• Personal Author:
  Emmett, Edward A. ; Rowse DH
• Description:
  The skin has assumed a more prominent role as a potential route for solvent exposure and uptake as respiratory exposure has been reduced through engineering controls and personal protective equipment. Skin architecture plays an important role in regulating solvent absorption. Key epidermal variables that influence solvent absorption include: SC thickness; cell packing/organization; lipid content; skin hydration; and the number/density of hair follicles and sweat glands. Solvent physical and chemical characteristics (molecular structure, pH, pKa, hydrophobicity, volatility) as well as solvent vehicle, solubility, duration of contact, occlusion and concentration are all important in assessing potential for skin penetration. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Occupational Health Personal Protective Equipment Safety Skin Solvents
• Keywords:
  Absorption Rates Chemical Hazards Dermal Absorption Dermal Exposures Exposure Methods Personal Protective Equipment PPE Skin Exposure
• ISSN:
  1526-0046
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  4
• Issue:
  4
• NIOSHTIC Number:
  nn:20053530
• Citation:
  Clin Occup Environ Med 2004 Dec; 4(4):657-730
• Contact Point Address:
  Debra H. Rowse, MD, MS, University of Pennsylvania Health System, Silverstein Pavilion, Ground Floor, 3400 Spruce Street, 4 Philadelphia, PA 19104-4238, USA
• Email:
  debra.rowse@uphs.upenn.edu
• Federal Fiscal Year:
  2005
• Performing Organization:
  University of Pennsylvania, Philadelphia
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Clinics in Occupational and Environmental Medicine
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c0a566d698a8eb6239c6f762fa2f9ce8b9d19b9cb15e4a6727367936477d53b8411cfd2d4337728b7ec1ff780aeec3aaf3f7515f3be65b39b4ca109c60114622
• Download URL:
  https://stacks.cdc.gov/view/cdc/216263/cdc_216263_DS1.pdf
• File Type:
  [PDF - 9.81 MB ]