Comparative Probabilistic Assessment of Occupational Pesticide Exposures Based on Regulatory Assessments

Details

• Personal Author:
  Cullen AC ; Fenske RA ; Kissel JC ; Pouzou JG ; Yost MG
• Description:
  Implementation of probabilistic analyses in exposure assessment can provide valuable insight into the risks of those at the extremes of population distributions, including more vulnerable or sensitive subgroups. Incorporation of these analyses into current regulatory methods for occupational pesticide exposure is enabled by the exposure data sets and associated data currently used in the risk assessment approach of the Environmental Protection Agency (EPA). Monte Carlo simulations were performed on exposure measurements from the Agricultural Handler Exposure Database and the Pesticide Handler Exposure Database along with data from the Exposure Factors Handbook and other sources to calculate exposure rates for three different neurotoxic compounds (azinphos methyl, acetamiprid, emamectin benzoate) across four pesticide-handling scenarios. Probabilistic estimates of doses were compared with the no observable effect levels used in the EPA occupational risk assessments. Some percentage of workers were predicted to exceed the level of concern for all three compounds: 54% for azinphos methyl, 5% for acetamiprid, and 20% for emamectin benzoate. This finding has implications for pesticide risk assessment and offers an alternative procedure that may be more protective of those at the extremes of exposure than the current approach. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Insecticides Nervous System Occupational Exposure Occupational Health Safety
• Keywords:
  Author Keywords: Occupational Exposure Exposure Assessment Exposure Levels Neurotoxic Agents Pesticides Pesticides And Agricultural Chemicals Probabilistic Exposure Assessment Regulations Regulatory Activities Risk Assessment
• ISSN:
  0272-4332
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  38
• Issue:
  6
• NIOSHTIC Number:
  nn:20053408
• Citation:
  Risk Anal 2018 Jun; 38(6):1223-1238
• Contact Point Address:
  Jane Pouzou, c/o Pacific Northwest Agricultural Safety and Health Center, Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington UW Box 357234, Seattle, WA 98195, USA
• Email:
  jgp42@u.washington.edu
• CAS Registry Number:
  Azinphos-methyl (CAS RN 86-50-0)
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Risk Analysis
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f21bf34eed61a149789442b9793285062a3d50b6c6388345edd4973699251de89697c722101bb34ac880e9ecf4e3663c34af4a8a84d177268a25a18f51574a1d
• Download URL:
  https://stacks.cdc.gov/view/cdc/216167/cdc_216167_DS1.pdf
• File Type:
  [PDF - 903.55 KB ]