Glucose Tolerance in Mice Exposed to Light-Dark Stimulus Patterns Mirroring Dayshift and Rotating Shift Schedules

Details

• Personal Author:
  Figueiro MG ; Plitnick B ; Radetsky L ; Rea MS
• Description:
  Glucose tolerance was measured in (nocturnal) mice exposed to light-dark stimulus patterns simulating those that (diurnal) humans would experience while working dayshift (DSS) and 2 rotating night shift patterns (1 rotating night shift per week [RSS1] and 3 rotating night shifts per week [RSS3]). Oral glucose tolerance tests were administered at the same time and light phase during the third week of each experimental session. In contrast to the RSS1 and RSS3 conditions, glucose levels reduced more quickly for the DSS condition. Glucose area-under-the-curve measured for the DSS condition was also significantly less than that for the RSS1 and RSS3 conditions. Circadian disruption for the 3 light-dark patterns was quantified using phasor magnitude based on the 24-h light-dark patterns and their associated activity-rest patterns. Circadian disruption for mice in the DSS condition was significantly less than that for the RSS1 and RSS3 conditions. This study extends previous studies showing that even 1 night of shift work decreases glucose tolerance and that circadian disruption is linked to glucose tolerance in mice. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Laboratories Lighting Occupational Health Safety Shift Work Schedule Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Activity Levels Biological Effects Biological Rhythms Circadian Rhythms Humans Laboratory Animals Laboratory Testing Lighting Systems Rest Periods Shift Work Shift Workers Sleep Deprivation Sleep Disorders Sugars Work Schedules

  More +
• ISSN:
  2045-2322
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• NIOSHTIC Number:
  nn:20053291
• Citation:
  Sci Rep 2017 Jan; 7:40661
• Contact Point Address:
  Mariana G. Figueiro, Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, USA
• Email:
  figuem@rpi.edu
• CAS Registry Number:
  Glucose (CAS RN 50-99-7)
• Federal Fiscal Year:
  2017
• NORA Priority Area:
  Healthcare and Social Assistance ; Transportation, Warehousing and Utilities
• Performing Organization:
  Rensselaer Polytechnic Institute, Troy, New York
• Peer Reviewed:
  True
• Start Date:
  20150901
• Source Full Name:
  Scientific Reports
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:53bddf75619b1066f79ab812cbf24d468a0e93474c9634d7e83554bbc034269dad87d47609bc85503eb963a437b7f77a2ac21dc27bf163b57b9b0d655d271411
• Download URL:
  https://stacks.cdc.gov/view/cdc/216081/cdc_216081_DS1.pdf
• File Type:
  [PDF - 756.17 KB ]