Use of Oxidative Lipidomics and Signaling by Oxidized Lipids in Safety Screening of Nanoparticles

Details

• Personal Author:
  Kagan VE
• Description:
  Engineered nanomaterials are becoming a pervasive presence in different spheres of modern life - from diverse technological applications to a plethora of consumer products - and this raises concerns about their possible adverse effects on human health and the environment. Among the different nanomaterials available today, carbon nanotubes (CNT), particularly single-walled carbon nanotubes (SWCNT), are most advanced and abundant in their applications. The unique physico-chemical characteristics combined with the vast surface area make the biological effects of CNT and their interactions with cells largely unpredictable. Therefore, the cytotoxicity of these novel nanomaterials cannot be readily deduced from previous investigations of other particles or fibers. In fact, in vitro data indicate that SWCNT may exert strong cytotoxicity with induction of oxidative stress. More importantly, recent in vivo studies have demonstrated robust and unusual pulmonary inflammatory responses of SWCNT upon exposure of mice via aspiration or inhalation. Inflammatory tissue responses were also observed when certain multi-walled CNT with high aspect ratios were administered to mice via intraperitoneal injection. Notably, myeloperoxidase of inflammatory cells, particulalry of neutrophils, is capable of effective CNT biodegradation to CO2 whereby both hypochlorous acid and reactive intermedates of the enzyme contribe to oxidative modification of CNT. Using an established mouse model of pharyngeal SWCNT aspiration, Dr. Kagan and colleagues showed that biodegradation of carbon nanotubes nullified their ability to induce characteristic pulmonary inflammatory responses. These findings strongly indicate that numerous novel biomedical applications of carbon nanotubes may be achievable under conditions of carefully controlled biodegradation. [Description provided by NIOSH]
• Subjects:
  Animals Cytotoxins Immune System Lung Occupational Health Oxidants Respiratory System Safety Toxicology
• Keywords:
  Animal Studies Biodegradation Biological Effects Carbon Nanotubes CNT Cytotoxic Effects Immune Reaction Nanomaterials Nanotoxicology Neutrophils Oxidative Processes Pulmonary Effects

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• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  5
• Volume:
  120
• NIOSHTIC Number:
  nn:20053288
• Citation:
  Toxicologist 2011 Mar; 120(Suppl 2):5
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  The Toxicologist. Society of Toxicology 50th Annual Meeting and ToxExpo, March 6-10, 2011, Washington, DC
• Supplement:
  2
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9133457237d483c407a98c3a74866a6510fde6f7ac24f2f9de77bb37fe758a5236679ef3e4cf72a6efc233594718589f8b537ff6952416a53d9ca05ad240c75b
• Download URL:
  https://stacks.cdc.gov/view/cdc/216079/cdc_216079_DS1.pdf
• File Type:
  [PDF - 1.13 MB ]