Carbon Nanotubes Enhance Metastatic Growth of Lung Carcinoma via Up-Regulation of Myeloid-Derived Suppressor Cells

Details

• Personal Author:
  Chen Y ; Gutkin D ; Kagan V ; Khaliullin T ; Kisin E ; Shurin G ; Shurin M ; Shvedova AA ; Stanley S ; Star A ; Tkach AV
• Description:
  Expanding applications of nanomaterials, particularly carbonaceous nanoparticles (CNP), in new technologies, consumer products and biomedicine, imply their increasing levels of manufacturing. There are numerous attempts to utilize nanoparticles for better delivery of drugs and nucleic acid-based therapeutics to disease sites in the lung, particularly to the lung epithelium. The inhalation of drug nano-formulations propelled the development of new strategies in therapy of several human lung diseases such as asthma, cystic fibrosis, chronic obstructive pulmonary disease, lung cancer, tuberculosis, etc. Safety and lack of adverse health effects remain the major pre-requisites for broader applications of these novel technologies. Toxicological assessments of nano-particles typically are performed on normal animals. Thus possible effects of CNP on tumor growth have not yet been considered. The immune system safeguards the host from infections and malignancies. Recognition and undesirable interactions of CNP with cells of the immune system may lead to immunomodulation, hence increasing the host's susceptibility to infections and cancer. Here, we show that single wall carbon nanotubes (SWCNT) promote metastatic establishment and growth of Lewis lung carcinoma in C57BL6/J mice. The effect was mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment. [Description provided by NIOSH]
• Subjects:
  Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety Toxicology
• Keywords:
  Carbon Nanofibers Cellular Effects CNF Lung Cancer Lung Disease Nanotechnology Therapeutic Agents
• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  98-99
• Volume:
  132
• Issue:
  1
• NIOSHTIC Number:
  nn:20053285
• Citation:
  Toxicologist 2013 Mar; 132(1):98-99
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  The Toxicologist. Society of Toxicology 52nd Annual Meeting and ToxExpo, March 10-14, 2013, San Antonio, Texas
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:917ef1482d09b7ff76b1ff9d5be658a1042b0828c696ab3e429fc85fa38369c5e5c0cfc993c7ed1d1f961100ec36768e354a2022f436ad23b9695d2be14f0292
• Download URL:
  https://stacks.cdc.gov/view/cdc/216076/cdc_216076_DS1.pdf
• File Type:
  [PDF - 2.46 MB ]