Influence of Farming Exposure on the Development of Asthma and Asthma-Like Symptoms

Details

• Personal Author:
  Poole JA ; Romberger DJ ; Wells AD
• Description:
  Based upon age and type of farming exposures, a wide range of studies demonstrate either protective or deleterious effects of the farming environment on asthma. In this review, we highlight key studies supporting the concept that farming exposure protects children from asthma and atopy based on studies performed largely in European pediatric cohorts. Various types of farming in certain regions appear to have a greater effect on asthma protection, as does the consumption of unpasteurized milk. In the United State, where concentrated animal feeding operations (CAFOs) are more common, asthma is increased in children exposed especially to swine CAFOs; whereas, rates of atopy and allergy are lower in these children. We also review studies evaluating the role of farming exposures both as a child and/or as an adult on asthma seen in adults. The importance of microbes in farming environments and the contribution of various components of the innate immune system including toll-like receptors to the underlying mechanisms of asthma related to farming exposures are also reviewed. [Description provided by NIOSH]
• Subjects:
  Age Factors Asthma Asthma, Occupational Dairy Products Farmers Hypersensitivity Immune System Livestock Occupational Health Safety
• Keywords:
  Age Factors Allergies Animal Husbandry Workers Atopy Author Keywords: Asthma Children Dairy Products Exposure Assessment Farming Farm Workers Immune System Innate Immunity Livestock Industry

  More +
• ISSN:
  1567-5769
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  356-363
• Volume:
  23
• Issue:
  1
• NIOSHTIC Number:
  nn:20053150
• Citation:
  Int Immunopharmacol 2014 Nov; 23(1):356-363
• Contact Point Address:
  Debra J. Romberger, Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, 985990 Nebraska Medical Center, Omaha, NE
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Nebraska Medical Center, Omaha, Nebraska
• Peer Reviewed:
  True
• Start Date:
  20060801
• Source Full Name:
  International Immunopharmacology
• End Date:
  20160731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:61e0d69b3aed7406eb970072de1a94515c93ca0a1c4584135a7f10635f9b3fc8bc43590d779d0fe978342636781b1e58d927ab802687adfbda3542cbcbdc7378
• Download URL:
  https://stacks.cdc.gov/view/cdc/215964/cdc_215964_DS1.pdf
• File Type:
  [PDF - 352.54 KB ]