Impacts of Risk Assessment Data, Assumptions, and Methods: Considering the Evidence for Diacetyl and 2,3-Pentanedione

Details

• Personal Author:
  Cox-Ganser, Jean M. ; Johns DO ; Whittaker C
• Description:
  The articles published as part of the Frontiers in Public Health research topic, "Investigating exposures and respiratory health in coffee workers" present research findings that better characterize exposures to diacetyl and 2,3-pentanedione and inform our understanding of the health risks posed by these exposures. Although various research groups and organizations have conducted risk assessments to derive occupational exposure limits (OELs) for diacetyl, differences in the data used and assumptions made in these efforts have resulted in a wide range of recommended OELs designed to protect human health. The primary drivers of these differences include the decision to use data from human or animal studies in conducting a quantitative risk assessment, and the application of uncertainty factors (UF) to derive an OEL. This Perspectives paper will discuss the practical implications of these decisions, and present additional commentary on the potential role that the recent investigation of human exposures to relatively low concentrations of a-diketones, specifically diacetyl and 2,3-pentanedione, may play in supporting qualitative or quantitative human health risk assessments. [Description provided by NIOSH]
• Subjects:
  Coffee Diacetyl Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  A-diketones Author Keywords: Risk Assessment Coffee Roasting And Packaging Coffee Workers Health Effects Lung Disease Occupational Exposure Limits Occupational Exposures OELs Respiratory Health Risk Assessment

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• Series:
  Mining Publications
• ISSN:
  2296-2565
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 5 ; Washington ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  SMRD - Spokane Mining Research Division ; DSI - Division of Science Integration ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  10
• NIOSHTIC Number:
  nn:20066123
• Citation:
  Front Public Health 2022 Sep; 10:972136
• Contact Point Address:
  Ryan F. LeBouf, Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, WV
• Email:
  djohns@cdc.gov
• CAS Registry Number:
  2,3-Pentanedione (CAS RN 600-14-6) ; Butanedione (CAS RN 431-03-8)
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Mining
• Peer Reviewed:
  True
• Source Full Name:
  Frontiers in Public Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d3d3968cc037e89c3359f73cd1ae7083621d55fd9cbdc93b254f19501c3086aa5595b3c2b40658a7027db55c463ff2a76097e38a12b82cfa76fddf819b9df27a
• Download URL:
  https://stacks.cdc.gov/view/cdc/215566/cdc_215566_DS1.pdf
• File Type:
  [PDF - 162.34 KB ]