Community Participatory-Based Reproductive Epidemiology Using DBCP Exposure as a Model

Details

• Personal Author:
  Kim PJ ; Lim KL ; Robbins WA ; Rodriguez J
• Description:
  We explored the feasibility of conducting a retrospective epidemiological study of adult reproductive effects following childhood environmental exposure to DBCP (dibromochloropropane). DBCP is a male reproductive toxicant used extensively as a pesticide during the 1970s in the San Joaquin Valley of California. Although adverse effects for adult occupational exposures are clear, new evidence suggests pre-pubescent and pubertal males may also be sensitive. It is not known if levels of DBCP found in the environment might have effects on the developing male reproductive system. To investigate this, we compiled a detailed retrospective, school-based, DBCP exposure matrix using drinking water and pesticide usage data from nearby agricultural fields. Public and private sources were used and cross-referenced to establish validity of exposure data. We then constructed a database containing names and current addresses of males who attended schools with high DBCP exposure (>/= 4 ppb drinking water) versus low exposure (<=/-0.001 ppb drinking water) during 1970 through 1981. Focus groups were conducted with community members to determine the most socio-culturally sensitive techniques to encourage participation in a research study that would ask for reproductive history information and donation of semen. Surveys were sent to 200 men in both high and low exposed schools to determine willingness to participate in a reproductive study and to elicit information that would improve participation. A field test of 25 men was conducted to document participation rates for reproductive history and semen collection. DBCP exposure provided a natural experiment in which to test feasibility to integrate current biologic monitoring with retrospective exposure assessment in environmental epidemiology studies. [Description provided by NIOSH]
• Subjects:
  Epidemiology Insecticides Occupational Health Safety Urogenital System
• Keywords:
  Biological Monitoring Community Based Drinking Water Exposure Assessment Pesticides And Agricultural Chemicals Reproductive Hazards
• ISSN:
  0893-6692
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  43
• Volume:
  37
• NIOSHTIC Number:
  nn:20057992
• Citation:
  Environ Mol Mutagen 2001 Mar; 37(Suppl 32):43
• Contact Point Address:
  PJ Kim, UCLA SPH-EHS 56-070, Box 951772, Los Angeles, CA 90095-1772
• CAS Registry Number:
  1,2-Dibromo-3-chloropropane (CAS RN 96-12-8)
• Federal Fiscal Year:
  2001
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  False
• Start Date:
  19990701
• Source Full Name:
  Environmental and Molecular Mutagenesis
• Supplement:
  32
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7a8b99c3595a03e09e9bce5b9061051589d4eb8b5a79fe2cd4e255a643d619c3091c93673d764e21ffcabc7bad2128e9cb3ec7e7676ff39c842d3d5841ca59ca
• Download URL:
  https://stacks.cdc.gov/view/cdc/215186/cdc_215186_DS1.pdf
• File Type:
  [PDF - 107.73 KB ]