Exposure to Cholinesterase-Inhibiting Agents as a Risk Factor for Development of Non-Hodgkin’s Lymphoma

Details

• Personal Author:
  Aoki Y
• Description:
  Organophosphates and carbamates widely used as insecticides exert their toxicity through inhibition of neuronal cholinesterase (ChE). Some epidemiological studies have shown exposure to these compounds may increase risk for non-Hodgkin's lymphoma (NHL). We investigated whether such exposure is associated with NHL risk in a general population. Resources of ongoing longitudinal studies based in Washington County, MD that have maintained banked blood specimens collected in 1974 and 1989, were used to examine this association. Pre-diagnostic samples from 98 NHL cases and 195 matched controls were analyzed for ChE specific activity in serum along with serum arylesterase and albumin. ChE specific activity was calculated as a unit-less ratio of ChE activity to ChE mass and thought to be inversely correlated with exposure to ChE inhibitors. Higher serum arylesterase might reduce NHL risk since some ChE inhibitors are detoxified by arylesterase. Contrary to the direction expected from previous results, cases had higher ChE specific activity; OR for each 0.1 increase in ChE specific activity (1/3 of its SD among controls) was 2.7 (95% CI, 1.3-5.7) after adjusting for arylesterase, albumin, education, and smoking for NHLs that occurred within 4.4 years since blood donation. For the same NHL subset, higher arylesterase activity had an apparent protective effect against NHL specific to arylesterase phenotype; for the phenotype G1 (QQ paraoxonase), OR for 10 (mOD/min) increase in arylesterase (roughly equal to its SD among controls) was 0.47 (95% CI, 0.28-0.79). For QR heterozygotes and RR heterozygotes, OR was closer to unity, 0.61 (95% CI, 0.41-0.91) and 0.63 (95% CI, 0.43-0.94), respectively. These associations were attenuated for NHLs with longer (>4.4 yrs) donation-to-diagnosis intervals. Higher albumin appeared protective overall but harmful for NHLs occurring at age 68-76 after multivariate adjustment. Apparent harmful effects of elevated ChE specific activity may be attributable to beneficial components in diet that inhibit ChE. Alternatively it could arise from a confounding variable such as vegetable/fruit intake, which is protective and associated with exposure to insecticide residues in fresh produce. Also, elevated levels of serum VLDL in preclinical NHL cases might have had an in vitro effect to increase ChE specific activity. [Description provided by NIOSH]
• Subjects:
  Carbamates Insecticides Neoplasms Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Cancer Rates Cholinesterase Inhibitors Health Effects Lymphatic Cancer Lymphatic System Disorders Organophosphorus Insecticides Risk Factors
• Publisher:
  ProQuest LLC.
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Dissertation
• Place as Subject:
  Maryland ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20057871
• Citation:
  Ann Arbor, MI: ProQuest LLC., 2004 Jan; :3130635
• Federal Fiscal Year:
  2004
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  False
• Start Date:
  19940701
• Source Full Name:
  Exposure to cholinesterase-inhibiting agents as a risk factor for development of non-Hodgkin's lymphoma
• End Date:
  20050630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f15115418e5e401a04984bffe2f4962b0df3c02911238662e3ad325855bcb6f10860e405b8270bb244ee2c8d972095ce06a344f1d024da80a8e25cee236724d6
• Download URL:
  https://stacks.cdc.gov/view/cdc/215077/cdc_215077_DS1.pdf
• File Type:
  [PDF - 6.47 MB ]