Determination of Four Quinones in Diesel Exhaust Particles, SRM 1649a, and Atmospheric PM2.5

Details

• Personal Author:
  Avol E ; Cho AK ; Di Stefano E ; Eiguren-Fernandez A ; Froines JR ; Kobayashi T ; Kumagai Y ; Miguel AH ; Rodriguez CE ; Schmitz DA ; You Y
• Description:
  Quinones are reactive organic compounds and are known to initiate reactions associated with many toxicological events. Their presence in air pollution has been demonstrated, but routine quantitative measurements are lacking. A quantitative method for the determination of four quinones was developed using diesel exhaust particles (DEP) and National Institute of Standards and Technology (NIST) Standard Reference Material (SRM) 1649a. The method was then used to analyze ambient air samples from different sites in Southern California. After extraction in dichloromethane, the target compounds were converted to their stable diacetyl derivatives and determined by electron impact GC-MS using selected ion monitoring. Calibration plots were obtained with deuterium-labeled internal standards. The four quinones, 1,2-naphthoquinone (1,2-NQ), 1,4-naphthoquinone (1,4-NQ), 9,10-phenanthraquinone (9,10-PQ), and 9,10-anthraquinone (9,10-AQ), were quantified in DEP, in SRM 1649a, and in ambient air samples of PM2.5 collected in several rural and urban sampling locations upwind and downwind of major emission sources in Central Los Angeles. Mean concentration of individual target quinones ranged from 7.9-40.4 ug/g in the DEP, and from 5-730 pg/m3 in the PM2.5 samples. Precision (repeatability and reproducibility) varied from 2-22%. Further measurements of these species in future air samples should be considered in light of their potential health significance. [Description provided by NIOSH]
• Subjects:
  Air Pollution Environmental Monitoring Occupational Health Quinones Safety Vehicle Emissions
• Keywords:
  Air Quality Measurement Air Sampling Air Sampling Techniques Diesel Exhausts Emission Sources Organic Compounds Quantitative Analysis
• ISSN:
  0278-6826
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  68-81
• Volume:
  38
• NIOSHTIC Number:
  nn:20057855
• Citation:
  Aerosol Sci Technol 2004 May; 38(Suppl 1):68-81
• Contact Point Address:
  Arthur K. Cho, Department of Molecular and Medical Pharmacology, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095
• Email:
  acho@mednet.ucla.edu
• Federal Fiscal Year:
  2004
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  Aerosol Science and Technology
• Supplement:
  1
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bc15d35b3e504c71ec3ba2ebbc37438a198daa17a8c0562906e2dac7c69b34f8b4ad8be6b83c4bb4d66951903acaa4db091a68da13d0b4467c56f5469a11352e
• Download URL:
  https://stacks.cdc.gov/view/cdc/215062/cdc_215062_DS1.pdf
• File Type:
  [PDF - 757.44 KB ]