Serum PCBs, P, P’-DDE and HCB Predict Thyroid Hormone Levels in Men

Details

• Personal Author:
  Altshul L ; Hauser R ; Meeker JD
• Description:
  Polychlorinated biphenyls (PCBs) and some organochlorine pesticides, which continue to be measurable in a high proportion of blood samples from the general population, have been found to alter thyroid hormone levels in animals and humans. However, studies of these relationships in adult men are limited and results across studies have been inconsistent. In the present study, we measured serum levels of 57 PCB congeners, dichlorodiphenyldichloroethylene (p,p(')-DDE, a stable metabolite of DDT), and hexachlorobenzene (HCB), as well as free T(4), total T(3), and TSH, in 341 adult men recruited from an infertility clinic from 2000 to 2003. In multivariate linear regression, there were positive associations between p,p(')-DDE and both free T(4) and total T(3), and an inverse association between p,p(')-DDE and TSH. Conversely, for PCBs there was only a suggestive inverse association between PCB 153 and total T(3) when potential confounding variables were considered. However, when results were additionally adjusted for p,p(')-DDE, inverse associations with T(3) were significant for PCB 138, PCB 153, sum of PCBs and three different PCB groupings, and HCB, while the positive associations between p,p(')-DDE and T(3) also remained. In conclusion, serum concentrations of PCBs, p,p(')-DDE, and HCB were associated with circulating thyroid hormone levels in adult men. [Description provided by NIOSH]
• Subjects:
  Animals Blood Endocrine System Environmental Exposure Environmental Pollution Hematologic Tests Insecticides Laboratories Men Occupational Health Polychlorinated Biphenyls Safety

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• Keywords:
  Author Keywords: DDE Blood Samples BMI Body Mass Index DDT Dichlorodiphenyltrichloroethane Environmental Pollution Hexachlorobenzene Hormone Hormones Humans Laboratory Animals Organochlorine Compounds PCB PCBs Pesticides Polychlorinated Biphenyls Thyroid Thyroid Gland

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  296-304
• Volume:
  104
• Issue:
  2
• NIOSHTIC Number:
  nn:20057767
• Citation:
  Environ Res 2007 Jun; 104(2):296-304
• Contact Point Address:
  John D. Meeker, Department of Environmental Health Sciences, University of Michigan, M6226 SPH II, 109 S. Observatory St., Ann Arbor, MI 48109
• Email:
  meekerj@umich.edu
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3) ; DDT (CAS RN 50-29-3) ; Hexachlorobenzene (CAS RN 118-74-1) ; p,p′-DDE (CAS RN 72-55-9)
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d401dd2499f89bab93ee4eb36a42b53d11dc74069e7162f98401d63d0ffbb2acddcf7ec477ab70f39b6c3ad7e4871008441bd9ec3d47c42a39859b600782ca56
• Download URL:
  https://stacks.cdc.gov/view/cdc/215001/cdc_215001_DS1.pdf
• File Type:
  [PDF - 239.21 KB ]