A Dynamic Radiographic Imaging Study of Lumbar Intervertebral Disc Morphometry and Deformation In Vivo

Details

• Personal Author:
  Aiyangar A ; Byrne RM ; Zhang X
• Description:
  Intervertebral discs are important structural components of the spine but also are significant sources of morbidity, especially for the "low back" lumbar region. Mechanical damage to, or degeneration of, the lumbar discs can diminish their structural integrity and elicit debilitating low back pain. Advancement of reparative or regenerative means to treat damaged or degenerated discs is hindered by a lack of basic understanding of the disc load-deformation characteristics in vivo. The current study presents an in vivo analysis of the morphometry and deformation of lumbar (L2-S1) intervertebral discs in 10 healthy participants while performing a common lifting act, using novel dynamic radiographic imaging of the lumbar vertebral body motion. Data analyses show uniquely different (p < 0.05) characteristics in morphometry, normal and shear strain patterns of the L5S1 discs, while the rest of lumbar discs exhibit great similarity. In particular shear strains in L2-L5 discs exhibited stronger linear correlations (R2 >/= 0.80) between strain changes and amount of lumbar flexion-extension motion compared to L5S1 (R2 ≤ 0.5). The study therefore advances the state of knowledge on in vivo mechanical responses of the lumbar intervertebral discs during functional tasks. [Description provided by NIOSH]
• Subjects:
  Biomechanical Phenomena Musculoskeletal System Nervous System Occupational Health Radiation Safety
• Keywords:
  3D Biochemical Indicators Biomechanical Modeling Body Mechanics Bone Structure Humans Imaging Techniques In Vivo Studies Lifting Low Back Disorders Low Back Pain Manual Lifting Models Morphology Motion Studies Physiological Factors Radiography Skeletal Movement Spinal Cord Task Performance Three Dimensional Weight Factors

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• ISSN:
  2045-2322
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; OSHA Region 6 ; Pennsylvania ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• NIOSHTIC Number:
  nn:20057658
• Citation:
  Sci Rep 2019 Oct; 9:15490
• Contact Point Address:
  Xudong Zhang, Department of Industrial & Systems Engineering, Texas A&M University, College Station, TX 77843, USA
• Email:
  xudongzhang@tamu.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20110901
• Source Full Name:
  Scientific Reports
• End Date:
  20140831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5e946f6693f61416ed9f069dcbbd7d91f3ea5cfa0f19d606504e40915e0f415178f161e2c4a22d3c7c570c036340ee48e6dc93b0dcfc51921f185a88b0331674
• Download URL:
  https://stacks.cdc.gov/view/cdc/214927/cdc_214927_DS1.pdf
• File Type:
  [PDF - 2.21 MB ]