Lifestyle of Women Before Pregnancy and the Risk of Offspring Obesity During Childhood Through Early Adulthood

Details

• Personal Author:
  Chavarro JE ; Dhana K ; Field AE ; Hu FB ; Schernhammer E ; Sun Q ; Wang X ; Yuan C ; Zhang C ; Zong G
• Description:
  Background: In women, adhering to an overall healthy lifestyle is associated with a dramatically reduced risk of cardio-metabolic disorders. Whether such a healthy lifestyle exerts an intergenerational effects on child health deserves examination. Methods: We included 5701 children (9-14 years old at baseline) of the Growing Up Today Study 2, and their mothers, who are participants in the Nurses' Health Study II. Pre-pregnancy healthy lifestyle was defined as a normal body mass index, no smoking, physical activity >/=150 min/week, and diet in the top 40% of the Alternative Healthy Eating Index-2010. Obesity during childhood and adolescence was defined using the International Obesity Task Force age- and sex-specific cutoffs. Multivariable log-binominal regression models with generalized estimating equations were used to evaluate the association of pre-pregnancy healthy lifestyle and offspring obesity. Results: We identified 520 (9.1%) offspring who became obese during follow-up. A healthy body weight of mothers and no smoking before pregnancy was significantly associated with a lower risk of obesity among offspring: the relative risks [RRs; 95% confidence intervals (CIs)] were 0.37 (0.31-0.43) and 0.64 (0.49-0.84), respectively. Eating a healthy diet and regular moderate-to-vigorous physical activities were inversely related to offspring obesity risk, but these relations were not statistically significant. Compared to children of mothers who did not meet any low-risk lifestyle factors, offspring of women who adhered to all four healthy lifestyle factors had 75% lower risk of obesity (RR: 0.25, 95% CI: 0.14-0.43). Conclusion: Adherence to an overall healthy lifestyle before pregnancy is strongly associated with a low risk of offspring obesity in childhood, adolescence, and early adulthood. These findings highlight the importance of an overall healthy lifestyle before pregnancy as a potential strategy to prevent obesity in future generations. [Description provided by NIOSH]
• Subjects:
  Body Weight Occupational Health Pregnancy Safety Women
• Keywords:
  Body Weight Children Health Effects Obesity Physical Fitness
• ISSN:
  0307-0565
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Massachusetts ; OSHA Region 1 ; OSHA Region 3 ; Rhode Island
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  42
• Issue:
  7
• NIOSHTIC Number:
  nn:20057576
• Citation:
  Int J Obesity 2018 Jul; 42(7):1275-1284
• Contact Point Address:
  Qi Sun, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
• Email:
  qisun@hsph.harvard.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  Brigham and Women's Hospital, Inc., Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20100801
• Source Full Name:
  International Journal of Obesity
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1b16d5bef7b846979ab75418f31e38410adcb38c58b425d9375eb3347a16e9ba8df9f988136abd3717e87b89618e81f49eeda748870b42514b506a3afece574b
• Download URL:
  https://stacks.cdc.gov/view/cdc/214866/cdc_214866_DS1.pdf
• File Type:
  [PDF - 535.77 KB ]