Complementary Biobank of Rodent Tissue Samples to Study the Effect of World Trade Center Exposure on Cancer Development

Details

• Personal Author:
  Brody R ; Chen L-C ; Cohen MD ; Gillezeau C ; Horton L ; Lee H-W ; Lieberman-Cribbin W ; Mulholland DJ ; Park S-H ; Prophete C ; Sisco M ; Taioli E ; Tuminello S ; van Gerwen M ; Zelikoff J
• Description:
  World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. New York University (NYU) and Mount Sinai have recreated WTC exposure in rodents to observe the resulting systemic and local biological responses. These experiments aid in the interpretation of epidemiological observations and are useful for understanding the carcinogenesis process in the exposed human WTC cohort. Here we describe the implementation of a tissue bank system for the rodents experimentally exposed to WTC dust. NYU samples were experimentally exposed to WTC dust via intratracheal inhalation that mimicked conditions in the immediate aftermath of the disaster. Tissue from Mount Sinai was derived from genetically modified mice exposed to WTC dust via nasal instillation. All processed tissues include annotations of the experimental design, WTC dust concentration/dose, exposure route and duration, genetic background of the rodent, and method of tissue isolation/storage. A biobank of tissue from rodents exposed to WTC dust has been compiled representing an important resource for the scientific community. The biobank remains available as a scientific resource for future research through established mechanisms for samples request and utilization. Studies using the WTC tissue bank would benefit from confirming their findings in corresponding tissues from organs of animals experimentally exposed to WTC dust. Studies on rodent tissues will advance the understanding of the biology of the tumors developed by WTC responders and ultimately impact the modalities of treatment, and the probability of success and survival of WTC cancer patients. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Cell Division Cells, Cultured Dust Emergency Responders Environmental Exposure Epidemiology Genetics Laboratories Neoplasms Occupational Health Pathology Risk Assessment Risk Factors Safety September 11 Terrorist Attacks

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• Keywords:
  Author Keywords: Rodents Biological Effects Biological Factors Biological Materials Biorepository Cancer Carcinogenesis Cell Cultures Cell Division Cell Proliferation Cellular Effects Chemicals Dust Exposure Dusts Emergency Responders Exposure Assessment Exposure Levels First Responders Genes Laboratory Animals Risk Factors Rodents Sample Preparation Tissue Culture Translational Research Tumors World Trade Center World Trade Center Dust WTC

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• ISSN:
  1479-5876
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  17
• NIOSHTIC Number:
  nn:20057492
• Citation:
  J Transl Med 2019 Oct; 17:342
• Contact Point Address:
  Emanuela Taioli, Institute for Translational Epidemiology and Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1133, New York, NY 10029, USA
• Email:
  emanuela.taioli@mountsinai.org
• Federal Fiscal Year:
  2020
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20180701
• Source Full Name:
  Journal of Translational Medicine
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:869f1497616dea8651b83f08729756fa2c8d75c606da48a68c30aa3464d2df8eb5e57db31465cc1742c5d7fc4c4b2b59d0cc237ab9fa3637548922ef3362ee6a
• Download URL:
  https://stacks.cdc.gov/view/cdc/214831/cdc_214831_DS1.pdf
• File Type:
  [PDF - 704.33 KB ]