High Parental Occupational Social Contact and Risk of Childhood Hematopoietic, Brain and Bone Cancers

Details

• Personal Author:
  Hansen J ; Heck JE ; Olsen J ; Omidakhsh N ; Ritz B
• Description:
  Background: The etiology of childhood cancer is largely unknown, though some research suggests an infectious origin of hematopoietic, central nervous system (CNS) and bone cancers. Methods: We examined parental occupational social contact as a proxy for exposure to infectious agents and risk of childhood cancer. This population-based case-control study utilized a linkage of four Danish data-registries, and included 3581 cases (<17 years, diagnosed 1973-2012) and 358,100 age-matched controls. We examined the risks of leukemia, lymphoma, CNS and bone cancer related to high occupational social contact from (1) conception to birth and (2) birth to diagnosis. Results: Acute lymphoblastic leukemia (ALL) and bone cancer were inversely associated with high maternal social contact from conception to birth (OR: 0.86, 95% CI: 0.67-1.10) and birth to diagnosis (OR: 0.54, 95% CI: 0.34-0.86). Children of fathers with high social contact from birth to diagnosis had an increased risk of bone cancers, particularly in rural areas (OR: 1.65, 95% CI: 1.03-2.63). Parental social contact was associated with increased risk of astrocytoma, with strongest associations found in first-born children (maternal: OR: 1.54, 95% CI: 1.02-2.32; paternal: OR: 1.82, 95% CI: 1.05-3.17). Conclusion: Our results support the notion of a role of infections for some cancer types. [Description provided by NIOSH]
• Subjects:
  Neoplasms Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Author Keywords: Pediatric Cancer Bone Cancer Cancer Rates Central Nervous System Disorders Central Nervous System Tumors Children Infectious Agents Leukemia Lymphatic Cancer Occupational Exposure Occupational Exposures Risk Factors Sociological Factors

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• ISSN:
  1877-7821
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  62
• NIOSHTIC Number:
  nn:20057432
• Citation:
  Cancer Epidemiol 2019 Oct; 62:101575
• Contact Point Address:
  Julia E. Heck, UCLA Department of Epidemiology, 650 Charles E Young Drive, Box 951772, Los Angeles, CA 90095-1772, USA
• Email:
  jeheck@ucla.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Cancer Epidemiology
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:61d081663ea02de64a3ce82c7c4d8e33266de3d134c757197b9901a754e83919d3dc3750463dd8e0714eec9cd6fb51ff819564390974efc6484ec1af2df770ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/214789/cdc_214789_DS1.pdf
• File Type:
  [PDF - 229.87 KB ]