Effects of Welding Fume Exposure on Human Placental Cells (Dataset)

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  As more women join the skilled-trade workforce, the effects of workplace exposures on pregnancy need to be explored. This study aimed to identify the effects of mild-steel (MS) and stainless-steel (SS) welding fume exposures on first-trimester placental trophoblast cells, using the HTR-8/SVneo cell line. MS is primarily composed of Iron (Fe) and Manganese (Mn), while SS also contains chromium (Cr) and nickel (Ni). We found that all three welding fumes had significant effects on cellular viability, and also caused increases in free radical production, while negatively affecting their invasive capabilities. MS was the only sample to cause an increase in production of the pro-inflammatory cytokines IL-6 and IL-8. Our results show that welding fume exposure is in fact cytotoxic to trophoblasts, and understanding how these occupational exposures could impact maternal and fetal health is necessary. Identifying how the varying combinations of heavy metals and other materials present in MS and SS welding fumes, along with fume particle size adversely affects the maternal fetal interface and gestational outcomes should be considered an emerging issue, and appropriate measures should be taken to reduce exposures in the workplace. [Description provided by NIOSH]
• Subjects:
  Cells, Cultured Chromium Metals Metals, Heavy Occupational Health Pregnancy Safety Urogenital Diseases Urogenital System Welding Women

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• Keywords:
  Cell Cultures Chromium Compounds Heavy Metals Humans Iron Compounds Manganese Compounds Nickel Compounds Reproductive Effects Reproductive Hazards Reproductive Health Reproductive System Disorders Welding Fumes Welding Industry

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• DOI:
  https://doi.org/10.26616/NIOSHRD-1012-2019-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20057424
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1012-2019-0, 2019 Oct; :dataset
• Contact Point Address:
  Nicole S. Olgun, PhD, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road, MS 2015, Morgantown, WV 26505
• Email:
  nolgun@cdc.gov
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3) ; Iron (CAS RN 7439-89-6) ; Manganese (CAS RN 7439-96-5) ; Nickel (CAS RN 7440-02-0)
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Effects of welding fume exposure on human placental cells
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:45efef8616c9907359c2703fc277dd9767ba46a503ae51bcf8f31af6a8d93a19d4cc60603a050bc6278d812d71420b9d16ffadc47c567c02efcc2ddd95450ded
• Download URL:
  https://stacks.cdc.gov/view/cdc/214781/cdc_214781_DS1.pdf
• File Type:
  [PDF - 129.46 KB ]