Chemical Identification and Confirmation of Contact Allergens

Details

• Personal Author:
  Law, Brandon F. ; Siegel, Paul D. ; Warshaw EM
• Description:
  dentification of the etiological chemical agent(s) associated with a case(s) of allergic contact dermatitis (ACD) is important for both patient management and public health surveillance. Traditional patch testing can identify chemical allergens to which the patient is allergic. Confirmation of allergen presence in the causative ACD-associated material is presently dependent on labeling information, which may not list the allergenic chemical on the product label or safety data sheet. Dermatologists have expressed concern over the lack of laboratory support for chemical allergen identification and possibly quantification from patients' ACD-associated products. The aim of this review was to provide the clinician a primer to better understand the analytical chemistry of contact allergen confirmation and unknown identification, including types of analyses, required instrumentation, identification levels of confidence decision tree, limitations, and costs. [Description provided by NIOSH]
• Subjects:
  Chemistry, Analytic Dermatitis Hazardous Substances Hypersensitivity Occupational Health Safety Skin Skin Diseases
• Keywords:
  Allergens Allergic Dermatitis Analytical Chemistry Chemical Agents Contact Allergies Contact Dermatitis Dermal Exposures Etiology Hazard Identification Hazard Labels Material Safety Data Sheets MSDSs Patch Tests Skin Exposure Skin Irritants Skin Tests Warning Signs

  More +
• ISSN:
  1710-3568
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  99-105
• Volume:
  31
• Issue:
  2
• NIOSHTIC Number:
  nn:20057084
• Citation:
  Dermatitis 2020 Mar/Apr; 31(2):99-105
• Contact Point Address:
  Paul D. Siegel, PhD, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505
• Email:
  pds3@cdc.gov
• Federal Fiscal Year:
  2020
• Peer Reviewed:
  True
• Source Full Name:
  Dermatitis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2f3370fbdd2ec9f462dfda48178cf8f8f1cde300e6e849301c2de23484a6087476c9612e0a71c9fa01f77fdd0d68a193b228ee368d7f9303cd42872924dfc49a
• Download URL:
  https://stacks.cdc.gov/view/cdc/214545/cdc_214545_DS1.pdf
• File Type:
  [PDF - 662.57 KB ]