Exposure to Graphene Nanoparticles Induces Changes in Measures of Vascular/Renal Function in a Load and Form-Dependent Manner in Mice

Details

• Personal Author:
  Barger M ; Krajnak, Kristine M. ; Roach KA ; Roberts, Jennifer R. ; Schwegler-Berry D ; Stefaniak, Aleksandr B. ; Waugh, Stacey
• Description:
  Graphenes isolated from crystalline graphite are used in several industries. Employees working in the production of graphenes may be at risk of developing respiratory problems attributed to inhalation or contact with particulate matter (PM). However, graphene nanoparticles might also enter the circulation and accumulate in other organs. The aim of this study was to examine how different forms of graphene affect peripheral vascular functions, generation of reactive oxygen species (ROS) and changes in gene expression that may be indicative of cardiovascular and/or renal dysfunction. In the first investigation, different doses of graphene nanoplatelets were administered to mice via oropharyngeal aspiration. These effects were compared to those of dispersion medium (DM) and carbon black (CB). Gene expression alterations were observed in the heart for CB and graphene; however, only CB produced changes in peripheral vascular function. In the second study, oxidized forms of graphene were administered. Both oxidized forms increased the sensitivity of peripheral blood vessels to adrenoreceptor-mediated vasoconstriction and induced changes in ROS levels in the heart. Based upon the results of these investigations, exposure to graphene nanoparticles produced physiological and alterations in ROS and gene expression that may lead to cardiovascular dysfunction. Evidence indicates that the effects of these particles may be dependent upon dose and graphene form to which an individual may be exposed to. [Description provided by NIOSH]
• Subjects:
  Blood Dust Environmental Exposure Laboratories Occupational Health Particulate Matter Respiratory System Safety Toxicology
• Keywords:
  Author Keywords: Graphene Inhalation Blood Vessels Carbon Black Cardiovascular Function Cell Alteration Circulatory System Dispersion Exposure Assessment Exposure Levels Gene Expression Graphene Graphite Heart Inhalation Kidney Function Laboratory Animals Nanoparticles Nanoplatelets Nanotechnology Nanotoxicology Oxidative Stress Oxides Particulate Dust Particulates Physiological Effects Reactive Oxygen Species Respiratory Irritants ROS Vascular Dysfunction

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• ISSN:
  1528-7394
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  82
• Issue:
  12
• NIOSHTIC Number:
  nn:20056891
• Citation:
  J Toxicol Environ Health A 2019 Aug; 82(12):711-726
• Contact Point Address:
  K. Krajnak, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
• Email:
  ksk1@cdc.gov
• CAS Registry Number:
  Carbon black (CAS RN 1333-86-4) ; Graphene (CAS RN 1034343-98-0) ; Graphite (CAS RN 7782-42-5)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing ; Healthcare and Social Assistance
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d2d6de98e2ddf87195893f15ed03d09a97f9eb6cfffa5a7cf7366c82d5c18c04fe34b3c6f63f004401be7d2d040a7252c6bc4d0dfe112f44797bd4ede08f50a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/214387/cdc_214387_DS1.pdf
• File Type:
  [PDF - 1.88 MB ]