Neuroinflammation Disorders Exacerbated by Environmental Stressors

Details

• Personal Author:
  Miller DB ; O'Callaghan JP
• Description:
  Neuroinflammation is a condition characterized by the elaboration of proinflammatory mediators within the central nervous system. Neuroinflammation has emerged as a dominant theme in contemporary neuroscience due to its association with neurodegenerative disease states such as Alzheimer's disease, Parkinson's disease and Huntington's disease. While neuroinflammation often is associated with damage to the CNS, it also can occur in the absence of neurodegeneration, e.g., in association with systemic infection. The "acute phase" inflammatory response to tissue injury or infections instigates neuroinflammation-driven "sickness behavior," i.e. a constellation of symptoms characterized by loss of appetite, fever, muscle pain, fatigue and cognitive problems. Typically, sickness behavior accompanies an inflammatory response that resolves quickly and serves to restore the body to homeostasis. However, recurring and sometimes chronic sickness behavior disorders can occur in the absence of an underlying cause or attendant neuropathology. Here, we review myalgic enchepalomyelitis/chronic fatigue syndrome (ME/CFS), Gulf War Illness (GWI), and chemobrain as examples of such disorders and propose that they can be exacerbated and perhaps initiated by a variety of environmental stressors. Diverse environmental stressors may disrupt the hypothalamic pituitary adrenal (HPA) axis and contribute to the degree and duration of a variety of neuroinflammation-driven diseases. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Fatigue Occupational Health Safety
• Keywords:
  Author Keywords: Chemobrain Central Nervous System Central Nervous System Disorders Environmental Exposure Environmental Stress GWI ME/CFS Neuroimmune Neuroinflammation Sickness Behavior Stressors

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• ISSN:
  0026-0495
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  100
• NIOSHTIC Number:
  nn:20056862
• Citation:
  Metab Clin Exp 2019 Nov; 100(Suppl):153951
• Contact Point Address:
  O'Callaghan, J.P.; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV
• Email:
  jdo5@cdc.gov
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Metabolism: Clinical and Experimental
• Supplement:
  Supplement
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:df0e95d5852d6a15e83326071661589f0bf961d2b4bb8de820f022d81678a3d7f5dc2b2122bdf961dc26e97020f2c232fd03ff8ffa8a1e8cc109af939a6d5b45
• Download URL:
  https://stacks.cdc.gov/view/cdc/214360/cdc_214360_DS1.pdf
• File Type:
  [PDF - 461.44 KB ]