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4-(Trifluoromethyl)-2,3, 5,6-Tetrafluorobenzyl Bromide as a New Electrophoric Derivatizing Reagent



Details

  • Personal Author:
  • Description:
    4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide (TMB) was synthesized in a single step from a,a,a,2,3,5,6- heptafluoro-p-xylene. The purpose of TTBB is to function as an analogue of pentafluorobenzyl bromide (PFBB) in electrophoric derivatization reactions prior to detection by gas chromatography-electron-capture negative ion mass spectrometry (GC-ECNI-MS). In more detail, it was anticipated that TTBB could be used along with, or as a substitute for, PFBB to help control some interferences and confirm results. This is because a TTBB-product (of an analyte) would have different retention and sometimes m/z characteristics than a corresponding PFBB product in GC-ECNI-MS, while the two products should be similar in their ease of formation and yields. Results demonstrating these expectations were achieved by derivatizing and detecting two analytes with these reagents: N7-(2-hydroxyethyl)xanthine, and 2,3-pyrenedicarboxylic acid. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0021-9673
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    400-404
  • Volume:
    641
  • Issue:
    2
  • NIOSHTIC Number:
    nn:20056725
  • Citation:
    J Chromatogr 1993 Jul; 641(2):400-404
  • Contact Point Address:
    Roger W. Giese, Department of Pharmaceutical Sciences in the Bouve Pharmacy and Health Sciences, and Barnett Institute, Northeastern University, 360 Huntington Avenue, Boston, MA 02115
  • Federal Fiscal Year:
    1993
  • Performing Organization:
    Northeastern University, Boston, Massachusetts
  • Peer Reviewed:
    True
  • Start Date:
    19910101
  • Source Full Name:
    Journal of Chromatography
  • End Date:
    19961130
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:5ff700e860da60943a6d5640344391a1cf86beb970584009740879e18ef1681443ce9d3026d048797a75b0a6b722f51a0093212aad0341d559dfb771e130b768
  • Download URL:
  • File Type:
    Filetype[PDF - 1.33 MB ]
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