Patient-Reported Outcomes in Meta-Analyses – Part 1: Assessing Risk of Bias and Combining Outcomes

Details

• Personal Author:
  Agarwal A ; Busse JW ; Guyatt GH ; Johnston BC ; Patrick DL ; Schünemann HJ
• Description:
  Systematic reviews and meta-analyses of randomized trials that include patient-reported outcomes (PROs) often provide crucial information for patients and clinicians facing challenging health care decisions. Based on emerging methods, guidance on combining PROs in meta-analysis is likely to enhance their usefulness. The objectives of this paper are: i) to describe PROs and why they are important for health care decision-making, ii) illustrate the key risk of bias issues that systematic reviewers should consider and, iii) address outcome characteristics of PROs and provide guidance for combining outcomes. We suggest a step-by-step approach to addressing issues of PROs in meta-analyses. Systematic reviewers should begin by asking themselves if trials have addressed all the important effects of treatment on patients' quality of life. If the trials have addressed PROs, have investigators chosen the appropriate instruments? In particular, does evidence suggest the PROs used are valid and responsive, and is the review free of outcome reporting bias? Systematic reviewers must then decide how to categorize PROs and when to pool results. [Description provided by NIOSH]
• Subjects:
  Decision Making Occupational Health Safety
• Keywords:
  Author Keywords: Patient-reported Outcomes Decision Making Health-related Quality Of Life Health Care Health Care Decision-making Meta-analysis Quality Of Life Statistical Analysis Systematic Review
• ISSN:
  1477-7525
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• NIOSHTIC Number:
  nn:20056704
• Citation:
  Health Qual Life Outcomes 2013 Jul; 11:109
• Contact Point Address:
  Bradley C Johnston, Department of Anesthesia and Pain Medicine, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
• Email:
  bradley.johnston@sickkids.ca
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Health and Quality of Life Outcomes
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5540319c67ada48234e1e4da315303a2ff64e198335dfb6a79576a64ff454acbc8f5f17b52b91b06ddbf71aaef28399fad9500b641ee7fa56d00cb2a5dcd7e39
• Download URL:
  https://stacks.cdc.gov/view/cdc/214256/cdc_214256_DS1.pdf
• File Type:
  [PDF - 613.49 KB ]