Future Research Directions in Pneumonia: NHLBI Working Group Report

Details

• Personal Author:
  Aggarwal NR ; Caler EV ; Christiani, David C. ; Cormier SA ; Crothers K ; Dela Cruz CS ; Doerschuk CM ; Evans SE ; Goldstein DR ; Khatri P ; Kobzik L ; Kolls JK ; Levy BD ; Metersky ML ; Mizgerd JP ; Niederman MS ; Nusrat R ; Orihuela CJ ; Peyrani P ; Prince AS ; Ramírez JA ; Ridge KM ; Sethi S ; Suratt BT ; Sznajder J ; Tsalik EL ; Walkey AJ ; Wunderink RG ; Yende S
• Description:
  Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although triggered by a pathogen, pneumonia often results from dysregulations of host defense that likely precede infection. The coordinated activities of immune resistance and tissue resilience then dictate whether and how pneumonia progresses or resolves. Inadequate or inappropriate host responses lead to more severe outcomes such as acute respiratory distress syndrome and to organ dysfunction beyond the lungs and over extended time frames after pathogen clearance, some of which increase the risk for subsequent pneumonia. Improved understanding of such host responses will guide the development of novel approaches for preventing and curing pneumonia and for mitigating the subsequent pulmonary and extrapulmonary complications of pneumonia. The NHLBI assembled a working group of extramural investigators to prioritize avenues of host-directed pneumonia research that should yield novel approaches for interrupting the cycle of unhealthy decline caused by pneumonia. This report summarizes the working group's specific recommendations in the areas of pneumonia susceptibility, host response, and consequences. Overarching goals include the development of more host-focused clinical approaches for preventing and treating pneumonia, the generation of predictive tools (for pneumonia occurrence, severity, and outcome), and the elucidation of mechanisms mediating immune resistance and tissue resilience in the lung. Specific areas of research are highlighted as especially promising for making advances against pneumonia. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Immune System Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Pneumonia Bacterial Infection Host Response Host Susceptibility Immune System Infectious Diseases Pathogens Pneumonia Pulmonary Disorders Viral Infection
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; California ; Connecticut ; Illinois ; Kentucky ; Louisiana ; Massachusetts ; New Jersey ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Texas ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  256-263
• Volume:
  198
• Issue:
  2
• NIOSHTIC Number:
  nn:20056607
• Citation:
  Am J Respir Crit Care Med 2018 Jul; 198(2):256-263
• Contact Point Address:
  Charles S. Dela Cruz, M.D., PhD., Pulmonary, Critical Care and Sleep Medicine, Center for Pulmonary Infection Research and Treatment, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, TACS441D, New Haven, CT 06520
• Email:
  charles.delacruz@yale.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3addaf7453f7722f1215b849b14c7cdd62461ea8b39e869974470e77be05a9900722a479e7b064ba7afeb2ec177b139f87630b359a86778977e6abd32665620e
• Download URL:
  https://stacks.cdc.gov/view/cdc/214182/cdc_214182_DS1.pdf
• File Type:
  [PDF - 573.43 KB ]