Phthalate Metabolite Exposures Among Immigrants Living in the United States: Findings from NHANES, 1999–2014

Details

• Personal Author:
  Adamkiewicz G ; Brown FM ; Chie L ; Chu MT ; Dodson RE ; James-Todd TM ; Mitro SD ; Adamkiewicz G ; Brown FM ; Chie L ; Chu MT ; Dodson RE ; James-Todd TM ; Mitro SD
• Description:
  Phthalates exposure has been linked to multiple health risks, and US immigrants may have different exposures to phthalates due to lifestyle differences. Urinary concentrations of eight phthalate metabolites (mono-ethyl phthalate [MEP], mono-n-butyl phthalate [MnBP], mono-isobutyl phthalate [MiBP], mono-(3-carboxypropyl) phthalate [MCPP], mono-benzyl phthalate [MBzP], mono-2-ethylhexyl phthalate [MEHP], mono-(2-ethyl-5-hydroxyhexyl) phthalate [MEHHP], mono-(2-ethyl-5-oxohexyl) phthalate [MEOHP]) were measured in 10318 US-born and 3511 foreign-born individuals from NHANES 1999-2014. Using multivariate adjusted linear regression, we assessed whether phthalate metabolite levels differed by nativity in the whole population, within racial/ethnic groups, and by years in the US. We also tested whether immigrant demographics predicted phthalate metabolite levels. In fully adjusted models, MEP, MnBP, and MiBP were significantly higher, and MBzP significantly lower, among immigrants than US-born participants. Among immigrants, MnBP and MiBP significantly declined with longer time in the US (Ptrend = 0.029 and Ptrend = 0.039, respectively), while MCPP and MBzP significantly rose (Ptrend = 0.019 and Ptrend = 0.043, respectively). Results within each racial/ethnic group were consistent with the whole population. Among immigrants, women had significantly higher metabolite levels than men (all p < 0.01), and MEP, MnBP, and MCPP differed by race/ethnicity. Due to higher phthalate exposures, immigrants may be especially vulnerable to phthalate-associated health problems. [Description provided by NIOSH]
• Subjects:
  Biomarkers Demography Emigration And Immigration Energy Metabolism Healthcare Disparities Occupational Health Phthalic Acids Race Factors Safety Sex Characteristics
• Keywords:
  Demographic Characteristics Exposure Assessment Gender Factors Health Disparities Immigrant Workers Metabolites Phthalates Racial Factors
• ISSN:
  1559-0631
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  71-82
• Volume:
  29
• Issue:
  1
• NIOSHTIC Number:
  nn:20056604
• Citation:
  J Expo Sci Environ Epidemiol 2019 Jan; 29(1):71-82
• Contact Point Address:
  Tamarra M. James-Todd, Population Health Sciences Program, Harvard University, Boston, MA, USA
• Email:
  tjtodd@hsph.harvard.edu
• CAS Registry Number:
  Mono(2-ethylhexyl) phthalate (CAS RN 4376-20-9) ; Monobenzyl phthalate (CAS RN 2528-16-7) ; Monobutyl phthalate (CAS RN 131-70-4) ; Monoethyl phthalate (CAS RN 2306-33-4) ; Monoisobutyl phthalate (CAS RN 30833-53-5) ; Mono(2-ethylhexyl) phthalate (CAS RN 4376-20-9) ; Monobenzyl phthalate (CAS RN 2528-16-7) ; Monobutyl phthalate (CAS RN 131-70-4) ; Monoethyl phthalate (CAS RN 2306-33-4) ; Monoisobutyl phthalate (CAS RN 30833-53-5)
• Federal Fiscal Year:
  2019
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Exposure Science and Environmental Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2d5064d343cebe09f5acab4f10337ce423280598f28dd363ce44d2ff3a3fd1c7f186a9630e831fae8dcb919bfc0887bc20f45c11dc0c5809b263c20eb322e753
• Download URL:
  https://stacks.cdc.gov/view/cdc/214181/cdc_214181_DS1.pdf
• File Type:
  [PDF - 676.13 KB ]