Re: ‘Application of the Key Characteristics of Carcinogens in Cancer Hazard Evaluation’: Response to Goodman, Lynch and Rhomberg

Details

• Personal Author:
  Beland FA ; Chiu WA ; Christiani, David C. ; Corpet DE ; Guyton KZ ; Ross MK ; Rusyn I ; Smith MT ; van den Berg M ; Beland FA ; Chiu WA ; Christiani, David C. ; Corpet DE ; Guyton KZ ; Ross MK ; Rusyn I ; Smith MT ; van den Berg M
• Description:
  Guyton et al. reviewed feasibility and limitations of applying the 10 key characteristics (KCs) of carcinogens, as identified by Smith et al., to the comprehensive search, screening and evaluation of mechanistic evidence in cancer hazard identification. To do so, we compiled methods and results of mechanistic data evaluations from eight recent IARC Monograph meetings in which a range of more than 30 diverse chemicals and complex exposures were classified into Group 1, 2A, 2B or 3 by expert Working Groups. For most of the 16 carcinogens classified in Group 1 or 2A in these meetings, a broad literature encompassing multiple KCs was identified. Mechanistic data were used as part of the overall evaluation to classify two substances (tetrabromobisphenol A and tetrachloroazobenzene) in Group 2A, both of which modulate receptor-mediated effects in combination with other KCs. Fewer studies were available for the 17 agents classified in Group 2B or 3, and only one Group 2B carcinogen (1-bromopropane) had strong evidence of more than one KC. In all, an approach based on the KCs of carcinogens had several strengths for addressing the recognized challenges in assembling and evaluating mechanistic studies, as well as identifying data gaps, but we also identified opportunities for improvement. A letter by Goodman, Lynch, and Rhomberg raises some issues with our article, asserting that there is a lack of validation of the approach and a lack of consideration of the quality and relevance of the mechanistic studies. We are pleased for the opportunity to provide clarifications in response. [Description provided by NIOSH]
• Subjects:
  Carcinogens Hazardous Substances Occupational Health Safety
• Keywords:
  Carcinogenicity Chemical Hazards Chemicals Hazardous Materials
• ISSN:
  0143-3334
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Arkansas ; California ; Massachusetts ; Mississippi ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  39
• Issue:
  8
• NIOSHTIC Number:
  nn:20056529
• Citation:
  Carcinogenesis 2018 Aug; 39(8):1091-1093
• Contact Point Address:
  Martyn T Smith, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA
• Email:
  martynts@berkeley.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Carcinogenesis
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4d55daae40e7ef0954239ddc60a71309ca2a8631ff1783589b54a7aa1397fe4d8f423a0f1eb9e2ebfe04af6b1ab2f226aa8cf1ba5c6ba2477f8e486a84fe4b73
• Download URL:
  https://stacks.cdc.gov/view/cdc/214120/cdc_214120_DS1.pdf
• File Type:
  [PDF - 99.44 KB ]