Multi-Walled Carbon Nanotube-Induced Gene Expression Biomarkers for Medical and Occupational Surveillance

Details

• Personal Author:
  Dong C ; Guo NL ; Porter DW ; Qian Y ; Raese R ; Singh S ; Snyder-Talkington BN ; Wolfarth MG
• Description:
  As the demand for multi-walled carbon nanotube (MWCNT) incorporation into industrial and biomedical applications increases, so does the potential for unintentional pulmonary MWCNT exposure, particularly among workers during manufacturing. Pulmonary exposure to MWCNTs raises the potential for development of lung inflammation, fibrosis, and cancer among those exposed; however, there are currently no effective biomarkers for detecting lung fibrosis or predicting the risk of lung cancer resulting from MWCNT exposure. To uncover potential mRNAs and miRNAs that could be used as markers of exposure, this study compared in vivo mRNA and miRNA expression in lung tissue and blood of mice exposed to MWCNTs with in vitro mRNA and miRNA expression from a co-culture model of human lung epithelial and microvascular cells, a system previously shown to have a higher overall genome-scale correlation with mRNA expression in mouse lungs than either cell type grown separately. Concordant mRNAs and miRNAs identified by this study could be used to drive future studies confirming human biomarkers of MWCNT exposure. These potential biomarkers could be used to assess overall worker health and predict the occurrence of MWCNT-induced diseases. [Description provided by NIOSH]
• Subjects:
  Animals Biomarkers Blood Environmental Exposure Fibrosis Genetics Laboratories Lung Lung Diseases Manufacturing And Industrial Facilities Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Author Keywords: Multi-walled Carbon Nanotubes Cancer Carbon Nanotubes CNT Exposure Levels Genes In Vitro Study In Vivo Study Laboratory Animals Lung Cancer Lung Fibrosis Lung Tissue Manufacturing Models Multi-walled Carbon Nanotubes MWCNT Pulmonary System Disorders Ribonucleic Acids Risk Factors RNA Surveillance

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• ISSN:
  1422-0067
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  20
• Issue:
  11
• NIOSHTIC Number:
  nn:20056388
• Citation:
  Int J Mol Sci 2019 May; 20(11):2635
• Contact Point Address:
  Nancy L. Guo, West Virginia University Cancer Institute, West Virginia University, Morgantown, WV 26506
• Email:
  lguo@hsc.wvu.edu
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  International Journal of Molecular Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:21ae6a4495eb50b0ff8f95434d00a06f72d502784e963c7d675d824bd117b1d1be1c8bff93d37e5a2d64d5d31384b7cc5952412eca95a5b2f52a2708c96e1039
• Download URL:
  https://stacks.cdc.gov/view/cdc/214005/cdc_214005_DS1.pdf
• File Type:
  [PDF - 612.18 KB ]