Development of a New Patient-Reported Outcome Measure in Sarcopenia

Details

• Personal Author:
  Chiou C-F ; Dale W ; Dennee-Sommers B ; Evans CJ ; Evans WJ ; Ferrell BR ; Fitzgerald KA ; Fried LP ; Gandra SR ; Patrick DL
• Description:
  Objective: The objective of this study was to develop a patient-reported outcome (PRO) to assess reduced muscle strength in sarcopenia. Design: Qualitative research study. Setting: University of Arkansas for Medical Sciences. Participants: Subjects with sarcopenia. Measurements: Adults aged 55 years and older with sarcopenia (n = 12) attended open-ended, concept elicitation interviews to characterize the functional effects of reduced muscle strength on their lives. The resulting qualitative data were analyzed using a qualitative analysis software program (Atlas.ti [Atlas.ti GmbH, Berlin, Germany]) and a common set of codes was developed to summarize the data. Subsequently, the initial PRO measure was drafted. Cognitive interviews were then conducted with additional sarcopenia subjects (n = 12) to refine the measure. Results: Qualitative interviews identified key concepts (eg, impacts) in the areas of activities of daily living, emotions, social activities, energy, balance, coordination, sleep, and strength. Based on data from the cognitive debriefing interviews (eg, understandability, relevance, suggestions to reword items), the PRO measure development team came to consensus on which items or parts of the instructions to retain, revise, or delete. The final measure included 14 items. Conclusion: The final PRO measure, the Age-Related Muscle Loss Questionnaire, can be used in both clinical practice and clinical trial settings to assess functional impacts of reduced muscle strength in sarcopenia. [Description provided by NIOSH]
• Subjects:
  Mining Occupational Health Safety Software
• Keywords:
  Age Groups Author Keywords: Patient-reported Outcome Computer Software Muscle Function Muscle Tissue Muscle Wasting Qualitative Analysis Sarcopenia
• ISSN:
  1525-8610
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; California ; Illinois ; Massachusetts ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  226-233
• Volume:
  12
• Issue:
  3
• NIOSHTIC Number:
  nn:20056385
• Citation:
  J Am Med Dir Assoc 2011 Mar; 12(3):226-233
• Contact Point Address:
  Christopher J. Evans, PhD, MPH, Mapi Values, 133 Portland Street, Boston, MA 02114
• Email:
  chris.evans@mapivalues.com
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of the American Medical Directors Association
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c6bac4462b130fc9916b9513bffa72ec115d86d6c4003fdd857f31b56b9cb4db5e4e1f1b8b6f2a8b61b55a283253cf8ac6fcbf7c89623af201e8a865ff7eae40
• Download URL:
  https://stacks.cdc.gov/view/cdc/214002/cdc_214002_DS1.pdf
• File Type:
  [PDF - 135.20 KB ]