Polybrominated Biphenyl Exposure and Menstrual Cycle Function

Details

• Personal Author:
  Howards PP ; Jacobson MH ; Kesner JS ; Manatunga AK ; Marcus M ; Meadows JW ; Spencer JB ; Taylor KC ; Terrell ML
• Description:
  BACKGROUND: Brominated flame retardants, including polybrominated biphenyls (PBB), are persistent compounds reported to affect sex hormones in animals; less is known about potential effects in humans. An industrial accident in 1973-1974 exposed Michigan residents to PBB through contaminated food. We examined whether this exposure to PBB had long-term effects on menstrual cycle function. METHODS: In 2004-06, we recruited reproductive-aged women in the Michigan PBB Registry who were not pregnant, lactating, or taking hormonal medications. Participants kept daily diaries and provided daily urine for up to 6 months. We assayed urine samples for estrone 3-glucuronide (E13G), pregnanediol 3-glucuronide (Pd3G), and follicle stimulating hormone (FSH). We fit linear mixed models among women aged 35-42 years to describe the relation between serum PBB levels and log-transformed, creatinine-adjusted daily endocrine levels among women who were premenarchal during the exposure incident in 1973-74 (n=70). RESULTS: We observed that high (>3.0 parts per billion (ppb)) and medium (>1.0-3.0 ppb) PBB exposure were associated with lower E13G levels across the menstrual cycle and lower FSH levels during the follicular phase, compared with low PBB exposure (=1.0 ppb). High PBB exposure was also associated with lower Pd3G levels across the cycle compared with low PBB exposure, whereas Pd3G levels were similar in women with medium and low PBB exposure. CONCLUSIONS: Our results are consistent with a hypothesized effect of exposure to an exogenous estrogen agonist but the modest sample size of the study requires cautious interpretation. [Description provided by NIOSH]
• Subjects:
  Aging Animals Endocrine System Environmental Exposure Occupational Health Polychlorinated Biphenyls Risk Assessment Risk Factors Safety Urine Women

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• Keywords:
  Age Groups Author Keywords: Biphenyl Compounds Estrone Exposure Levels Follicular Phase Hormones Humans Luteal Phase Menstrual Cycle Menstrual Disorders Models Organic Chemicals PCBs Polybrominated Biphenyls Polychlorinated Biphenyls Risk Factors Sexual Reproduction Urinalysis

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• ISSN:
  1044-3983
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Kentucky ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  30
• Issue:
  5
• NIOSHTIC Number:
  nn:20056340
• Citation:
  Epidemiology 2019 Sep; 30(5):687-694
• Contact Point Address:
  Penelope Howards, Epidemiology Department, Emory University, 1518 lifton Rd, NE, CNR 3029, Atlanta, GA 30322
• Email:
  penelope.howards@emory.edu
• CAS Registry Number:
  Biphenyl (CAS RN 92-52-4)
• Federal Fiscal Year:
  2019
• Peer Reviewed:
  True
• Source Full Name:
  Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b3caf4840962478a35deb2b58b39ea584a72e8290d85caacd953cf3a500d9ead2a5d32b52ad5a7190eff8fbf357ab5523a2b0137dc63480d88ed976014b5fe05
• Download URL:
  https://stacks.cdc.gov/view/cdc/213964/cdc_213964_DS1.pdf
• File Type:
  [PDF - 210.78 KB ]