Genetic Predisposition to Parkinson’s Disease: CYP2D6 and HFE in the Faroe Islands

Details

• Personal Author:
  Brosen K ; Grandjean P ; Halling J ; Petersen MS ; Weihe P ; Brosen K ; Grandjean P ; Halling J ; Petersen MS ; Weihe P
• Description:
  OBJECTIVE: To investigate whether the genetic variants of CYP2D6 and HFE are more frequent in Parkinson's disease (PD) patients compared with controls in a population where the prevalence of these variants and PD are increased. METHODS: Blood samples were collected from 79 PD patients and 154 controls in the Faroe Islands. Genotyping for the 'CYP2D6*3, *4, *6 and *9' alleles and for the C282Y and H63D mutations were performed by real-time polymerase chain reaction before Taqman assessment. RESULTS: The frequency of CYP2D6 poor metabolizers among the patients was not higher compared with the frequency found in the control group (chi2 test, P=0.86). The odds ratio was 0.92 (95% confidence interval: 0.44-1.90). Neither was a difference in HFE genotype or allele frequencies found between the patients and the controls, and the C282Y and H63D mutation carrier frequencies did not reveal any difference (chi2 test, P=0.50 and 0.60, respectively). CONCLUSION: This study does not support an association between PD and mutations of the CYP2D6 and HFE genes, although a weak association cannot be excluded. The high frequency of PD in the Faroes is most likely the result of interactions between multiple genetic and environmental factors, still to be identified. [Description provided by NIOSH]
• Subjects:
  Blood Environment Environmental Exposure Genetics Hematologic Tests Men Occupational Health Risk Assessment Risk Factors Safety Women

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• Keywords:
  Author Keywords: CYP2D6 Polymorphism Blood Samples Environmental Factors Etiology Exposure Levels Faroe Islands Genetic Factors HFE Humans Parkinsons Disease Risk Factors

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• ISSN:
  1744-6872
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  209-212
• Volume:
  18
• Issue:
  3
• NIOSHTIC Number:
  nn:20056306
• Citation:
  Pharmacogenet Genomics 2008 Mar; 18(3):209-212
• Contact Point Address:
  Jo'nrit Halling, MSc, Clinical Pharmacology, Faculty of Health Sciences, Institute of Public Health, University of Southern Denmark, Winslowparken 19, DK-5000 Odense C, Denmark
• Email:
  jhalling@health.sdu.dk
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Pharmacogenetics and Genomics
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:225b018e77bd600b1c8999606201a6ecb7a6723e1dab986520ca0839055b655b83d492895f34efb7821860c25d38bb14e9db3e9f1ab5b844b504adcea9ea5069
• Download URL:
  https://stacks.cdc.gov/view/cdc/213936/cdc_213936_DS1.pdf
• File Type:
  [PDF - 76.30 KB ]