Spinal Substance P and Neurokinin-1 Increase with High Repetition Reaching

Details

• Personal Author:
  Barbe MF ; Barr AE ; Elliott MB
• Description:
  Musculoskeletal injury and inflammation is associated with performance of repetitive and forceful tasks. In this study, we examined the effects of performing a voluntary, highly repetitive, negligible force (HRNF) reaching task on spinal cord neurochemicals involved in nociception. To our knowledge, no other laboratories are examining spinal cord nociceptive neurochemicals in response to repetitive motion-induced injury and inflammation. The purpose of this study was to extend our earlier findings related to central neurotransmitters from a low demand task to a higher demand task. Specifically, this study determined immunoreactivity of a peptidergic pro-nociceptive transmitter (substance P) and one of its receptors, neurokinin-1 (NK-1) receptor, in spinal cord dorsal horns in rats performing a HRNF reaching task for 6-10 weeks. The relationship of these spinal cord changes with the number of TNFa immunopositive cells in flexor forelimb muscles and with previously observed forearm grip strength changes from these same rats were examined. Performance of the HRNF task resulted in significantly increased substance P and NK-1 receptor immunoreactivity in the superficial lamina of spinal cord dorsal horns at 6 and 10 weeks compared to trained controls (p < 0.01). The increased substance P and NK-1 receptor immmunoreactivity were positively correlated with declines in forearm grip strength, an assay of movement-related hyperalgesia (r = 0.70, p < 0.01 and r = 0.64, p < 0.05, respectively). The increased substance P and NK-1 receptor immmunoreactivity were also positively correlated with increased TNF immunopositive cells in forelimb flexor muscles (r = 0.85, p < 0.001 and r = 0.88, p < 0.001, respectively). Thus, our highly repetitive task leads to increased spinal cord pro-nociceptive neurochemicals that are most likely directed by forelimb muscle inflammation and pain. [Description provided by NIOSH]
• Subjects:
  Immune System Laboratories Musculoskeletal Diseases Musculoskeletal System Nervous System Occupational Health Safety
• Keywords:
  Author Keywords: Neurochemicals Grip Strength Hyperalgesia Immune Reaction Laboratory Animals MSD Muscle Tissue Musculoskeletal Disorders Neurological Reactions Neurotransmitters Repetitive Motion Injury Repetitive Work Spinal Cord Upper Extremities

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• ISSN:
  0304-3940
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  33-37
• Volume:
  454
• Issue:
  1
• NIOSHTIC Number:
  nn:20056289
• Citation:
  Neurosci Lett 2019 Apr; 454(1):33-37
• Contact Point Address:
  Melanie B. Elliott, Department of Physical Therapy, Temple University, 3307 North Broad St., Philadelphia, PA 19140, United States
• Email:
  mdion@temple.edu
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Construction ; Manufacturing
• Performing Organization:
  Temple University
• Peer Reviewed:
  True
• Start Date:
  20000601
• Source Full Name:
  Neuroscience Letters
• End Date:
  20120731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fad0d5723510eb904f99542c64b043792ec46040c407e35eef9a8fdc7f56042681cc62450b0ade03aab240253fe618b2d078354ad17c09984c4c6eb22209b384
• Download URL:
  https://stacks.cdc.gov/view/cdc/213925/cdc_213925_DS1.pdf
• File Type:
  [PDF - 638.80 KB ]