Inflammation Reduces Physiological Tissue Tolerance in the Development of Work-Related Musculoskeletal Disorders

Details

• Personal Author:
  Barbe MF ; Barr AE
• Description:
  Work-related musculoskeletal disorders (MSDs) cause substantial worker discomfort, disability and loss of productivity. Due to the difficulty in analyzing the tissues of patients in the early stages of work-related MSD, there is controversy concerning the pathomechanisms of the development of these disorders. The pathophysiology of work-related MSD can be studied more easily in animal models. The purpose of this review is to relate theories of the development of tissue injury due to repeated motion to findings of recent investigations in animals that address the role of the inflammatory response in propagating tissue injury and contributing to chronic or recurring tissue injury. These tissue effects are related to behavioral indicators of discomfort and movement dysfunction with the aim of clarifying key time points for specific intervention approaches. The results from animal models of MSD are discussed in the light of findings in patients, whose tissues are examined at a much later phase of MSD development. Finally, a conceptual model of the potentially negative impact of inflammation on tissue tolerance is proposed along with suggestions for future research directions. [Description provided by NIOSH]
• Subjects:
  Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Animal Models Author Keywords: Work-related Musculoskeletal Disorders Inflammation Laboratory Animals MSD Muscle Tissue Musculoskeletal Disorders Pathophysiology Physiological Effects Repetitive Motion Disorders Repetitive Work Tissue Injury Upper Extremities

  More +
• ISSN:
  1050-6411
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  77-85
• Volume:
  14
• Issue:
  1
• NIOSHTIC Number:
  nn:20056280
• Citation:
  J Electromyogr Kinesiol 2004 Feb; 14(1):77-85
• Contact Point Address:
  Ann E. Barr, Physical Therapy Department, College of Health Professions, Temple University, 3307, North Broad Street, Philadelphia, PA 19147, USA
• Email:
  aebarr@temple.edu
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Performing Organization:
  Temple University
• Peer Reviewed:
  True
• Start Date:
  20000601
• Source Full Name:
  Journal of Electromyography and Kinesiology
• End Date:
  20120731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:87c95ab5615f38e90999e571e9f906c0371930d0b8055ed5e2239b15c6646a52cb94ef8607b89102983c9578c35abac51b9127337447e538c937a9a5fd515f4f
• Download URL:
  https://stacks.cdc.gov/view/cdc/213917/cdc_213917_DS1.pdf
• File Type:
  [PDF - 319.88 KB ]