A Measurement of the Unstirred Aqueous Boundary Layer in a Franz Diffusion Cell

Details

• Personal Author:
  Kasting G ; Miller MA
• Description:
  The unstirred aqueous boundary layer (ABL) thickness was determined for modified Franz diffusion cells using three test compounds-parathion, 4-hexylresorcinol, and 2,4-dinitrochlorobenzene (DNCB). Steady-state fluxes through one, two, and three dialysis membranes in series were achieved in donor-saturated, infinite-dose permeation experiments. These results were then used to calculate the total diffusive resistance for each case, as well as an extrapolated zero membrane value which was used in conjunction with an estimate of the aqueous diffusivities to calculate the ABL thickness. The resulting value (mean +/- SE) was 0.070 +/- 0.004 cm. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Boundary Layer Diffusion Diffusion Cell Hexyl Compounds In Vitro Methodology In Vitro Study Parathion Permeation Skin Absorption Skin Tests
• ISSN:
  1083-7450
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  17
• Issue:
  6
• NIOSHTIC Number:
  nn:20056123
• Citation:
  Pharm Dev Technol 2012 Nov-Dec; 17(6):705-711
• Contact Point Address:
  Matthew Alexander Miller, Department of Pharmaceutical Sciences, University of Cincinnati, James L. Winkle College of Pharmacy, Academic Health Center, 3225 Eden Avenue, Cincinnati, 45267-0004, OH, USA
• CAS Registry Number:
  Parathion (CAS RN 56-38-2)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Agriculture, Forestry and Fishing ; Manufacturing
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Pharmaceutical Development and Technology
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b7d4bb09c2f7fabebbf15c0066b0125e66ce840d3c0d1218e2abd5ea9599fb629e99961ca6eda74dd80d6ee9eb6ba7788905c2e87dd70d3a66de959a6f4e1b49
• Download URL:
  https://stacks.cdc.gov/view/cdc/213791/cdc_213791_DS1.pdf
• File Type:
  [PDF - 903.74 KB ]