Thermodynamics of Water Interaction with Human Stratum Corneum I: Measurement by Isothermal Calorimetry

Details

• Personal Author:
  Kasting GB ; Pinto NG ; Yadav S
• Description:
  A thermodynamic study of water interaction with human stratum corneum (SC) is presented. The procedure consisted of conjoint water vapor sorption and heat flow measurements. Heat of sorption of water in excised human SC at various relative humidities was measured in an isothermal calorimeter at 32 degrees C using back and thigh skin from three different donors. These measurements, combined with the gravimetric sorption isotherm, were used to calculate the integral and differential enthalpies and entropies associated with binding of water to SC. Differential enthalpy values suggest hydrogen-bonding interactions similar to those for water in wool keratin. The changes in differential enthalpy and entropy with increasing water content followed a pattern similar to that seen in wool and other hydrophilic polymers. The results are partially interpreted in terms of a BET isotherm with monolayer volume vm = 0.022 g H2O/g dry SC and binding parameter C = 6.5 x 108. [Description provided by NIOSH]
• Subjects:
  Humidity Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Stratum Corneum Calorimetry Heat Of Sorption Humans Skin Absorption Thermodynamic Properties Thermodynamics Water Analysis Water Sorption
• ISSN:
  0022-3549
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  96
• Issue:
  6
• NIOSHTIC Number:
  nn:20056118
• Citation:
  J Pharm Sci 2007 Jun; 96(6):1585-1597
• Contact Point Address:
  Gerald B. Kasting, College of Pharmacy, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0004
• Email:
  Gerald.Kasting@uc.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Journal of Pharmaceutical Sciences
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:59b4a16331b4ff752857c46114c714bef50e21285866fe822e75b4bf35dd8af62601148e4bce825aba9c1e6447e642823f1c34c8324cf9fc044597cab04b0013
• Download URL:
  https://stacks.cdc.gov/view/cdc/213786/cdc_213786_DS1.pdf
• File Type:
  [PDF - 265.30 KB ]