Characterization of Dermal Absorption Following Decontamination via Washing

Details

• Personal Author:
  Kilcline EC ; Kissel JC ; Shirai J
• Description:
  Under current worker protection regulations and agricultural risk assessment paradigms, washing is assumed to be an effective method for removal toxic substances such as pesticides from the skin. These assumptions are based on accumulated experimental data and general chemical principles. However, washing also increases dermal hydration, which has been shown to change the effectiveness of the skin as a barrier. This in turn could alter transport of chemicals through the skin. Some investigators have argued that washing may be contraindicated under some circumstances, complicating advice to laborers. In order to further clarify the effect of washing on dermal absorption, an extensive literature review was conducted on existing washing studies. Studies using human volunteers or skin and multiple exposure durations provided the most applicable information. Original data are have also been generated via an exposure study that investigates the effect of washing on the dermal absorption of the insect repellent N,N-Diethyl-meta-toluamide (DEET). In this study, human subjects were exposed to a low or high loading level of DEET (5 or 30 ug/cm2 of skin) for either 10 or 40 minutes. Following the exposure period, the contaminated skin was washed with either water only, a 5% (v/v) soap and water solution or a 10% (v/v) ethanol and water solution. Twenty-four hour urine samples were collected for 5 days and are being analyzed for DEET parent compound and metabolites to determine the amount of chemical absorbed. Available washing data are also being evaluated using an original model of skin decontamination developed in MATLAB(R). That model permits examination of post exposure chemical transport to an aqueous surfactant solution placed on the skin. [Description provided by NIOSH]
• Subjects:
  Insecticides Occupational Health Safety Skin Skin Absorption
• Keywords:
  Author Keywords: Exposure Assessment DEET Dermal Exposures Exposure Modeling Hand Washing Models N,N-diethyl-meta-toluamide Pesticides And Agricultural Chemicals Skin Absorption
• Publisher:
  International Society of Exposure Science
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 10 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  294-295
• NIOSHTIC Number:
  nn:20056082
• Citation:
  21st Annual Meeting of the International Society of Exposure Science (ISES 2011): Advancing Exposure Science for Environmental Health, October 23-27, 2011, Baltimore, Maryland. Ottawa, Canada: International Society of Exposure Science, 2011 Oct; :294-295
• CAS Registry Number:
  N,N-Diethyl-m-toluamide (CAS RN 134-62-3)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing ; Agriculture, Forestry and Fishing
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  20020901
• Source Full Name:
  21st Annual Meeting of the International Society of Exposure Science (ISES 2011): Advancing Exposure Science for Environmental Health, October 23-27, 2011, Baltimore, Maryland
• End Date:
  20130731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9f05ac7b2daab8029f7e472a12608ebb0625ed5f6a66098c056aa3561012f91e71f4633b234c2a8bb712310e9292d174837d51309fb6ba01514079c9248f9e2b
• Download URL:
  https://stacks.cdc.gov/view/cdc/213770/cdc_213770_DS1.pdf
• File Type:
  [PDF - 84.25 KB ]