Blood Cadmium and Moderate-to-Severe Glomerular Dysfunction in Korean Adults: Analysis of KNHANES 2005–2008 Data

Details

• Personal Author:
  Baker, Dean B. ; Choi B ; Kim H-R ; Myong J-P
• Description:
  Purpose: The objective of this study was to evaluate the association between blood cadmium (Cd) and moderate-to-severe glomerular dysfunction in a Korean population using a representative sample. Methods: A cross-sectional study was used to evaluate the association between blood Cd and glomerular dysfunction. Based on the Korean National Health and Nutrition Examination Survey (2005-2008), individual blood Cd was measured in 2,992 adults, aged between 20 and 65. Results: After adjusting for survey years, age, sociodemographic factors, and health behaviors, the odds ratio for moderate-to-severe glomerular dysfunction (<60 mL/min per 1.73 m2) was 1.97 (95% CI: 1.28-3.07) when comparing the highest with the lowest blood Cd quartile in Korean women. However, in Korean men, there was no association between blood Cd and moderate-to-severe glomerular dysfunction. Conclusions: These findings support the consideration of Cd as a risk factor for glomerular dysfunction in the female population. Furthermore, environmental heavy metal monitoring and an institutional strategy should be implemented to reduce Cd exposure in the general population. [Description provided by NIOSH]
• Subjects:
  Cadmium Environmental Exposure Men Metals, Heavy Occupational Health Safety Women
• Keywords:
  Author Keywords: Cadmium Cross Sectional Studies Exposure Levels Glomerular Filtration Rate Heavy Metals Kidney Diseases Kidney Disorders KNHANES
• ISSN:
  0340-0131
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  85
• Issue:
  8
• NIOSHTIC Number:
  nn:20056040
• Citation:
  Int Arch Occup Environ Health 2012 Nov; 85(8):885-893
• Contact Point Address:
  H. W. Yim, Department of Preventive Medicine and Clinical Research Center for Depression, College of Medicine, The Catholic University of Korea, 505 BanPo-dong Seocho-gu, Seoul 137-701, Republic of Korea
• Email:
  cyclor@catholic.ac.kr
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9)
• Federal Fiscal Year:
  2013
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Archives of Occupational and Environmental Health
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8ac9ada2a3698a5b2b87bd17bb5d89d625243fce1778925925ad66d7a559fd018e9af8c3b32a8f1f96bd3f1e4cd4e5cd159f276e1c6062240aa2b09f140a0977
• Download URL:
  https://stacks.cdc.gov/view/cdc/213737/cdc_213737_DS1.pdf
• File Type:
  [PDF - 397.38 KB ]