Concepts and Challenges in Cancer Risk Prediction for the Space Radiation Environment

Details

• Personal Author:
  Barcellos-Hoff MH ; Blakely EA ; Burma S ; Fornace AJ Jr. ; Gerson S ; Hlatky L ; Kirsch DG ; Luderer U ; Shay J ; Wang Y ; Weil MM
• Description:
  Cancer is an important long-term risk for astronauts exposed to protons and high-energy charged particles during travel and residence on asteroids, the moon, and other planets. NASA's Biomedical Critical Path Roadmap defines the carcinogenic risks of radiation exposure as one of four type I risks. A type I risk represents a demonstrated, serious problem with no countermeasure concepts, and may be a potential "show-stopper" for long duration spaceflight. Estimating the carcinogenic risks for humans who will be exposed to heavy ions during deep space exploration has very large uncertainties at present. There are no human data that address risk from extended exposure to complex radiation fields. The overarching goal in this area to improve risk modeling is to provide biological insight and mechanistic analysis of radiation quality effects on carcinogenesis. Understanding mechanisms will provide routes to modeling and predicting risk and designing countermeasures. This white paper reviews broad issues related to experimental models and concepts in space radiation carcinogenesis as well as the current state of the field to place into context recent findings and concepts derived from the NASA Space Radiation Program. [Description provided by NIOSH]
• Subjects:
  Carcinogens Neoplasms Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Astronauts Author Keywords: Galactic Cosmic Radiation Cancer Carcinogenesis Mouse Models Radiation Exposure Radiation Quality Risk Factors Risk Modeling
• ISSN:
  2214-5524
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; District of Columbia ; Georgia ; Massachusetts ; New York ; North Carolina ; Ohio ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 8 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  92-103
• Volume:
  6
• NIOSHTIC Number:
  nn:20055910
• Citation:
  Life Sci Space Res 2015 Jul; 6:92-103
• Contact Point Address:
  Mary Helen Barcellos-Hoff, Department of Radiation Oncology, New York University School of Medicine, 450 E. 29th Street, New York, NY 10016, USA
• Email:
  mhbarcellos-hoff@nyumc.org
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Life Sciences in Space Research
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b9d6830f9985f47be50d095034281f5f5064d7bc24b385e239e82c0d4a7e670420183412db04cd82093541fa62c9e027b86cbf83568ee45ad2a554166220c22a
• Download URL:
  https://stacks.cdc.gov/view/cdc/213664/cdc_213664_DS1.pdf
• File Type:
  [PDF - 623.65 KB ]