Methylmercury Toxicity and Functional Programming

Details

• Personal Author:
  Grandjean P
• Description:
  PURPOSE: Adverse health effects of developmental toxicants may induce abnormal functional programming that leads to lasting functional deficits. This notion is considered from epidemiological evidence using developmental methylmercury neurotoxicity as an example. MOST IMPORTANT FINDINGS: Accumulating evidence indicates that adverse effects may occur even at low-level methylmercury exposures from seafood and freshwater fish. Neurobehavioral outcomes are usually non-specific, and imprecise exposure assessment results in a bias toward the null. Essential nutrients may promote the development of certain brain functions, thereby causing confounding bias. The functional deficits caused by prenatal methylmercury exposure appear to be permanent, and their extent may depend on the joint effect of toxicants and nutrients. PRINCIPA CONCLUSIONS: The lasting functional changes caused by neurodevelopmental methylmercury toxicity fit into the pattern of functional programming, with effects opposite to those linked to beneficial stimuli. Comment in: Ethylmercury and breastfeeding as confounders in outcomes of functional programming: Where are they? [Reprod Toxicol. 2008] [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Epidemiology Hazardous Substances Men Nervous System Nervous System Diseases Occupational Health Pregnancy Preventive Medicine Risk Assessment Risk Factors Safety Women

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• Keywords:
  Author Keywords: Adolescent Child Food Contamination Brain Damage Brain Disorders Environmental Exposure Etiology Exposure Levels Health Effects Humans Mercury Poisoning Methylmercury Compounds Nervous System Neurological Disorders Neuropsychological Tests Neurotoxic Effects Neurotoxicity Neurotoxicity Syndromes Nutrition Prenatal Exposure Prenatal Exposure Delayed Effects Preventive Medicine Risk Factors Toxic Effects Toxins

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• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  414-420
• Volume:
  23
• Issue:
  3
• NIOSHTIC Number:
  nn:20055844
• Citation:
  Reprod Toxicol 2007 Apr-May; 23(3):414-420
• Contact Point Address:
  Philippe Grandjean, Department of Environmental Health, Harvard School of Public Health, Landmark Center, 3-110E, 401 Park Drive, Boston, MA 02215
• Email:
  pgrandjean@health.sdu.dk
• CAS Registry Number:
  Methylmercury(1+) (CAS RN 22967-92-6)
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:45e24befa3225f79d2aef218a89cf8f174899999c10603ab9d523311d2fe9025daa3fca30fd95862076233d24a1d1b76835a5f0258994e8a714a97e29f229b77
• Download URL:
  https://stacks.cdc.gov/view/cdc/213609/cdc_213609_DS1.pdf
• File Type:
  [PDF - 146.86 KB ]