Night Shift Work Before and During Pregnancy in Relation to Depression and Anxiety in Adolescent and Young Adult Offspring

Details

• Personal Author:
  Devore EE ; Eliassen AH ; Okereke OI ; Rosner B ; Schernhammer ES ; Strohmaier S ; Vetter C
• Description:
  We investigated the relationship between maternal history of nightshift work before and shift work during pregnancy and offspring risk of depression and anxiety, among mothers participating in the Nurses Health Study II and in their offspring enrolled in the Growing Up Today Study 2 between 2004 and 2013. Case definitions were based on offspring self-reports of physician/clinician-diagnosed depression and/or anxiety, regular antidepressant use and depressive symptoms assessed using the Center for Epidemiologic Studies Depression Scale. Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using generalized estimating equation models. We found no associations between maternal nightshift work before pregnancy or during pregnancy and offspring mental health disorders (e.g., nightshift work before pregnancy: depression (based on physician/clinician diagnosis): ORever nightwork = 1.14; 95% CI, 0.88-1.47; either depression or anxiety: ORever nightwork = 0.93; 95% CI, 0.81-1.08; nightshift work during pregnancy: depression: ORever nightwork = 1.14; 95% CI, 0.68-1.94; depression or anxiety: ORever nightwork =1.17; 95% CI, 0.70-1.98) and no dose-response relationship with longer history of nightshift work (all PTrend >0.10). Stratifying by maternal chronotype revealed a higher risk of depression for offspring whose mothers worked nightshifts before pregnancy and reported being definite morning chronotypes (a proxy for circadian strain) ( ORever nightwork = 1.95; 95% CI, 1.17, 3.24 vs. ORever nightwork = 0.93; 95% CI, 0.68, 1.28 for any other chronotype; PInteraction = 0.03). Further studies replicating our findings and refined understanding regarding the interplay of nightshift work and chronotype and its potential influences on offspring mental health are needed. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Diagnosis Epidemiology Health Personnel Mental Disorders Mental Health Nervous System Occupational Health Pregnancy Safety Shift Work Schedule Women

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• Keywords:
  Antidepressants Author Keywords: Circadian Disruption Biological Effects Children Circadian Rhythms Clinical Diagnosis Intergenerational Mental Disorders Mental Health Night Shift Work Nurses Offspring Mental Health Psychological Disorders Psychological Responses Shift Work Shift Workers Statistical Analysis Stress

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• ISSN:
  0393-2990
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Massachusetts ; OSHA Region 1 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  34
• Issue:
  7
• NIOSHTIC Number:
  nn:20055820
• Citation:
  Eur J Epidemiol 2019 Jul; 34(7):625-635
• Contact Point Address:
  Eva S. Schernhammer, Department of Epidemiology, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna, Austria
• Email:
  eva.schernhammer@meduniwien.ac.at
• Federal Fiscal Year:
  2019
• Performing Organization:
  Brigham and Women's Hospital, Inc., Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20100801
• Source Full Name:
  European Journal of Epidemiology
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:21c410f51dcda1ffe1c167c2738a97c4e67ac34c3fe4e475fcd462dc343ff81de68556d171ee2a9c2c2e2dabf41aa778fd218ab6f571f7c2214462b3eb46faa4
• Download URL:
  https://stacks.cdc.gov/view/cdc/213588/cdc_213588_DS1.pdf
• File Type:
  [PDF - 1.00 MB ]