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Redefining Environmental Exposure for Disease Etiology



Details

  • Personal Author:
    Rappaport SM
  • Description:
    Etiological studies of human exposures to environmental factors typically rely on low-throughput methods that target only a few hundred chemicals or mixtures. In this Perspectives article, I outline how environmental exposure can be defined by the blood exposome-the totality of chemicals circulating in blood. The blood exposome consists of chemicals derived from both endogenous and exogenous sources. Endogenous chemicals are represented by the human proteome and metabolome, which establish homeostatic networks of functional molecules. Exogenous chemicals arise from diet, vitamins, drugs, pathogens, microbiota, pollution, and lifestyle factors, and can be measured in blood as subsets of the proteome, metabolome, metals, macromolecular adducts, and foreign DNA and RNA. To conduct 'exposome-wide association studies', blood samples should be obtained prospectively from subjects-preferably at critical stages of life-and then analyzed in incident disease cases and matched controls to find discriminating exposures. Results from recent metabolomic investigations of archived blood illustrate our ability to discover potentially causal exposures with current technologies. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    2056-7189
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    30
  • Volume:
    4
  • NIOSHTIC Number:
    nn:20055804
  • Citation:
    NPJ Syst Biol Appl 2018 Sep; 4:30
  • Contact Point Address:
    Stephen M. Rappaport, Program in Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
  • Email:
    srappaport@berkeley.edu
  • Federal Fiscal Year:
    2018
  • Performing Organization:
    University of California, Berkeley
  • Peer Reviewed:
    True
  • Start Date:
    20050701
  • Source Full Name:
    NPJ Systems Biology and Applications
  • End Date:
    20250630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:68cd12632fca8cc0656de366560f212b5eccef1c56ad92ef625ac12655a3255d0ff6d16a09dd99ba30418592a69da19293b7300ac8651422b3fb6b4d63647ddc
  • Download URL:
  • File Type:
    Filetype[PDF - 155.41 KB ]
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