Time to Onset of Paresthesia Among Community Members Exposed to the World Trade Center Disaster

Details

• Personal Author:
  Marmor M ; Reibman J ; Shao Y ; Thawani S ; Wang B
• Description:
  We examined whether time to onset of paresthesia was associated with indicators of severity of World Trade Center (WTC) exposure. We analyzed data from 3411 patients from the Bellevue Hospital-WTC Environmental Health Center. Paresthesia was defined as present if the symptom occurred in the lower extremities with frequency "often" or "almost continuous." We plotted hazard functions and used the log-rank test to compare time to onset of paresthesia between different exposure groups. We also used Cox regression analysis to examine risk factors for time-to-paresthesia after 9/11/2001 and calculate hazard ratios adjusted for potential confounders. We found significantly elevated hazard ratios for paresthesia for (a) working in a job that required cleaning of WTC dust in the workplace; and (b) being heavily exposed to WTC dust on September 11, 2001, after adjusting for age, race/ethnicity, depression, anxiety, post-traumatic stress disorder, and body mass index. These observational data are consistent with the hypothesis that exposure to WTC dust or some other aspect of cleaning WTC dust in the workplace, is associated with neuropathy and paresthesia. Further neurological evaluations of this and other WTC-exposed populations is warranted. [Description provided by NIOSH]
• Subjects:
  Dust Emergency Responders Environmental Exposure Nervous System Nervous System Diseases Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: Paresthesia Center Exposure Cox Regression Dust Exposure Dusts Environmental Exposure First Responders Hazard Function Neurological Disorders Neuropathic Symptoms Neuropathy Rescue Workers World Trade World Trade Center WTC

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• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  16
• Issue:
  8
• NIOSHTIC Number:
  nn:20055594
• Citation:
  Int J Environ Res Public Health 2019 Apr; 16(8):1429
• Contact Point Address:
  Michael Marmor, Department of Neurology, New York University School of Medicine, New York, NY 10017
• Email:
  michael.marmor@nyulangone.org
• Federal Fiscal Year:
  2019
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20130701
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:32217be8f9307a88af9573d4fecacad17ace2328b1c6553cc4e2e5fc891f7d4baebe876e8f62812bf7c0d744e4cccebe24c55daaf2f211d6659dbf11573648f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/213411/cdc_213411_DS1.pdf
• File Type:
  [PDF - 529.28 KB ]